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Erlin2 Gene Detail
Summary
  • Symbol
    Erlin2
  • Name
    ER lipid raft associated 2
  • Synonyms
    MGC:27952, Spfh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387215
    NCBI Gene: 244373
  • Gene Overview
    MyGene.info: ERLIN2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27023266-27039437 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 15.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387215
protein coding gene Chr8:27023261-27040328 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033499
protein coding gene Chr8:25197586-25216776 (+)
A/J MGP_AJ_G0033479
protein coding gene Chr8:24242102-24257716 (+)
AKR/J MGP_AKRJ_G0033404
protein coding gene Chr8:25042585-25058223 (+)
BALB/cJ MGP_BALBcJ_G0033475
protein coding gene Chr8:24398660-24414294 (+)
C3H/HeJ MGP_C3HHeJ_G0033189
protein coding gene Chr8:25263287-25278952 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033991
protein coding gene Chr8:26182883-26198499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030941
protein coding gene Chr8:21496001-21511593 (+)
CAST/EiJ MGP_CASTEiJ_G0032515
protein coding gene Chr8:24750816-24763629 (+)
CBA/J MGP_CBAJ_G0033164
protein coding gene Chr8:27215330-27233243 (+)
DBA/2J MGP_DBA2J_G0033319
protein coding gene Chr8:24205485-24221183 (+)
FVB/NJ MGP_FVBNJ_G0033263
protein coding gene Chr8:24019133-24034794 (+)
LP/J MGP_LPJ_G0033408
protein coding gene Chr8:25161176-25176829 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033306
protein coding gene Chr8:26662062-26678129 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034010
protein coding gene Chr8:25029022-25044676 (+)
PWK/PhJ MGP_PWKPhJ_G0032226
protein coding gene Chr8:23867507-23880366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032060
protein coding gene Chr8:24409374-24426598 (+)
WSB/EiJ MGP_WSBEiJ_G0032631
protein coding gene Chr8:25209060-25224696 (+)



Homology
more
  • Human Ortholog
    ERLIN2, ER lipid raft associated 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERLIN2, ER lipid raft associated 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C8orf2, Erlin-2, NET32, SPFH2, SPG18
  • Links
    NCBI Gene ID: 11160
    neXtProt AC: NX_O94905
    UniProt: O94905

  • Chr Location
    8p11.23; chr8:37736579-37757801 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5193
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ERLIN2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ERLIN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244373 NCBI Gene Model | MGI Sequence Detail 16172 C57BL/6J ±  kb
transcript NM_001364476 RefSeq | MGI Sequence Detail 4186 C57BL/6  
polypeptide Q8BFZ9 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 140
    cDNA 140

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142881
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:223306 Yang B, et al., The critical role of membralin in postnatal motor neuron survival and disease. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory