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Erlin2
Gene Detail
 Symbol
Name
ID
Erlin2
ER lipid raft associated 2
MGI:2387215
Synonyms MGC:27952, Spfh2
Feature Type protein coding gene
Genetic Map
Chromosome 8
15.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:27023799-27039433 bp, + strand
From Ensembl annotation of GRCm38

  15635 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Erlin2

Human
homologs
Human Homolog ERLIN2, ER lipid raft associated 2
NCBI Gene ID 11160
neXtProt AC  NX_O94905
Human Synonyms  C8orf2, Erlin-2, NET32, SPFH2, SPG18
Human Chr (Location)  8p11.2; chr8:37736227-37757801 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ERLIN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Erlin2 interacts with 321 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process ER-associated ubiquitin-dependent protein catabolic process
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) cDNA(139)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031483 (Evidence)
Entrez Gene244373 (Evidence)
UniGene277699
DFCITC1572887
DoTSDT.111176176, DT.489798
NIA Mouse Gene IndexU009212
Consensus CDS ProjectCCDS22209.1
International Mouse Knockout Project StatusErlin2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031483 Ensembl Gene Model | MGI Sequence Detail 15635 C57BL/6J ±  kb
transcript ENSMUST00000033873 Ensembl | MGI Sequence Detail 3943 Not Applicable 
polypeptide ENSMUSP00000033873 Ensembl | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(1)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001107 Band 7 protein
Protein Ontology PR:000007181 erlin-2
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:208296 Huber MD, et al., Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. J Cell Biol. 2013 Nov 11;203(3):427-36
All references(38)
Other
accession IDs
MGI:2142881

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory