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Dirc2 Gene Detail
Summary
  • Symbol
    Dirc2
  • Name
    disrupted in renal carcinoma 2 (human)
  • Synonyms
    MGC:47126, RCC4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387188
    NCBI Gene: 224132
Location & Maps
more
  • Sequence Map
    Chr16:35694062-35769356 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75295 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 25.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DIRC2, disrupted in renal carcinoma 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DIRC2, disrupted in renal carcinoma 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RCC4
  • Links
    NCBI Gene ID: 84925
    neXtProt AC: NX_Q96SL1

  • Chr Location
    3q21.1; chr3:122795054-122881139 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DIRC2 associations

Human Disease Mouse Models
       Renal Cell Carcinoma, Nonpapillary; RCC   OMIM: 144700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030298 VEGA Gene Model | MGI Sequence Detail 75295 C57BL/6J ±  kb
transcript OTTMUST00000075008 VEGA | MGI Sequence Detail 5395 Not Applicable  
polypeptide OTTMUSP00000039250 VEGA | MGI Sequence Detail 478 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    867 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006490 disrupted in renal carcinoma protein 2
  • InterPro Domains
    IPR020846 Major facilitator superfamily domain
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 7
References
more
  • Summaries
    All 28
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory