About   Help   FAQ
Dirc2
Gene Detail
Symbol

Name
ID
Dirc2
disrupted in renal carcinoma 2 (human)
MGI:2387188
Synonyms
MGC:47126, RCC4
Feature Type
protein coding gene
Genetic Map
Chromosome 16
25.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:35694062-35769356 bp, - strand
From VEGA annotation of GRCm38

  75295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DIRC2
Gene Tree: Dirc2

Human
homologs
DIRC2, disrupted in renal carcinoma 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84925
neXtProt AC: NX_Q96SL1

Human Synonyms: RCC4

Human Chr (Location): 3q21.1; chr3:122795054-122881139 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DIRC2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(25) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Dirc2 interacts with 339 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process transport
Component integral component of membrane, lysosome, ...
Function molecular_function
External Resources: FuncBase
Expression
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dirc2 ; ZFIN dirc2    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000030298 (Evidence)
Ensembl Gene Model ENSMUSG00000022848 (Evidence)
Entrez Gene 224132 (Evidence)
DFCI TC1577741, TC1651115, TC1682040, TC1754387
DoTS DT.110728390, DT.110728447, DT.532384
NIA Mouse Gene Index U037009
Consensus CDS Project CCDS28141.1
International Mouse Phenotyping Consortium Status Dirc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030298 VEGA Gene Model | MGI Sequence Detail 75295 C57BL/6J ±  kb
transcript OTTMUST00000075008 VEGA | MGI Sequence Detail 5395 Not Applicable 
polypeptide OTTMUSP00000039250 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(875 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000006490 disrupted in renal carcinoma protein 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory