Dusp9 MGI Mouse Gene Detail - MGI:2387107 - dual specificity phosphatase 9

Symbol

Dusp9
Name

dual specificity phosphatase 9
Synonyms

Mpk4, Pyst3

Feature Type

protein coding gene
IDs

MGI:2387107
NCBI Gene: 75590
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

ChrX:72683025-72687120 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.37 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

102 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387107	protein coding gene	ChrX:72682995-72687120 (+)
129S1/SvImJ	ENSMUSG00200041086	protein coding gene	ChrX:54743302-54747403 (+)
A/J	ENSMUSG00195032372	protein coding gene	ChrX:58419603-58423698 (+)
AKR/J	ENSMUSG00220043759	protein coding gene	ChrX:53721913-53726008 (+)
BALB/cJ	ENSMUSG00180048190	protein coding gene	ChrX:55000330-55004425 (+)
C3H/HeJ	ENSMUSG00175030482	protein coding gene	ChrX:58584008-58588103 (+)
C57BL/6NJ	ENSMUSG00215036267	protein coding gene	ChrX:55084178-55088271 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033153	protein coding gene	ChrX:68644401-68648465 (+)
CAST/EiJ	ENSTCUG00005042055	protein coding gene	ChrX:56501058-56505158 (+)
CBA/J	ENSMUSG00210037355	protein coding gene	ChrX:55264673-55268768 (+)
DBA/2J	ENSMUSG00185030767	protein coding gene	ChrX:67686320-67690415 (+)
FVB/NJ	ENSMUSG00205038632	protein coding gene	ChrX:54565652-54569747 (+)
JF1/MsJ	ENSUMUG00000021996	protein coding gene	ChrX:88426011-88430081 (+)
LP/J	ENSMUSG00230030843	protein coding gene	ChrX:74265466-74269567 (+)
NOD/ShiLtJ	ENSMUSG00190035368	protein coding gene	ChrX:54504684-54508779 (+)
NZO/HlLtJ	ENSMUSG00225046755	protein coding gene	ChrX:79469829-79473930 (+)
PWK/PhJ	ENSLUMG00010043863	protein coding gene	ChrX:54247220-54251275 (+)
SPRET/EiJ	ENSMSPG00010029458	protein coding gene	ChrX:57329646-57333754 (+)
WSB/EiJ	ENSIUOG00005048295	protein coding gene	ChrX:55329707-55333804 (+)

Human Ortholog

DUSP9, dual specificity phosphatase 9

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP9, dual specificity phosphatase 9
Synonyms

MKP-4, MKP4
Links

HGNC:3076

NCBI Gene ID: 1852

UniProt: Q99956
Chr Location

Xq28; chrX:153642401-153651326 (+) GRCh38

MGI Vertebrate Homology

Dusp9 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DUSP9
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp9

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

1
Targeted

6
Transgenic

1
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

883
Tissues

184
cDNA Data

47
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp9

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS30206.1

Ensembl

ENSMUSG00000031383 (Evidence)
NCBI Gene

75590

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031383	Ensembl Gene Model \| MGI Sequence Detail	4096	C57BL/6J	± kb
transcript	ENSMUST00000019701	Ensembl \| MGI Sequence Detail	2722	Not Applicable
polypeptide	ENSMUSP00000019701	Ensembl \| MGI Sequence Detail	452	Not Applicable

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UniProt

2 Sequences
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 52

Genomic 1

cDNA 47

Primer pair 3

Other 1

Antibodies 1

Microarray probesets 12

Summaries

All 47

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 12
Earliest

J:76596 Dickinson RJ, et al., Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. Biochem J. 2002 May 15;364(Pt 1):145-55
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dusp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161261	ChrX:72682994-72683001 (+)	-27 bp
Tssr161262	ChrX:72683004-72683016 (+)	-15 bp
Tssr161263	ChrX:72683020-72683042 (+)	6 bp
Tssr161264	ChrX:72683045-72683048 (+)	22 bp
Tssr161265	ChrX:72683723-72683735 (+)	704 bp
Tssr161266	ChrX:72683767-72683778 (+)	748 bp
Tssr161267	ChrX:72683784-72683792 (+)	763 bp
Tssr161268	ChrX:72683976-72683983 (+)	955 bp
Tssr161269	ChrX:72684357-72684388 (+)	1,348 bp
Tssr161270	ChrX:72685056-72685068 (+)	2,037 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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