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Gipc3 Gene Detail
Summary
  • Symbol
    Gipc3
  • Name
    GIPC PDZ domain containing family, member 3
  • Synonyms
    Ahl5, Gipc3, Rgs19ip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387006
    NCBI Gene: 209047
  • Gene Overview
    MyGene.info: GIPC3
Location & Maps
more
  • Sequence Map
    Chr10:81337762-81343266 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5505 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GIPC3, GIPC PDZ domain containing family member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GIPC3, GIPC PDZ domain containing family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C19orf64, DFNB15, DFNB72, DFNB95
  • Links
    NCBI Gene ID: 126326
    neXtProt AC: NX_Q8TF64

  • Chr Location
    19p13.3; chr19:3585541-3593541 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GIPC3 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 15; DFNB15   OMIM: 601869
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • QTL
    2
  • Targeted
    3
  • Genomic Mutations
    1 involving Gipc3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase gipc3
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027857 VEGA Gene Model | MGI Sequence Detail 5505 C57BL/6J ±  kb
transcript OTTMUST00000068972 VEGA | MGI Sequence Detail 1024 Not Applicable  
polypeptide OTTMUSP00000034973 VEGA | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030378 PDZ domain-containing protein GIPC3
  • InterPro Domains
    IPR001478 PDZ domain
    IPR017379 Uncharacterised conserved protein UCP038083, PDZ
Molecular
Reagents
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  • All nucleic 2
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:3514193
References
more
  • Summaries
    All 24
    Developmental Gene Expression 3
    Phenotypes 12
  • Earliest
    J:78673 Saitoh T, et al., Molecular cloning and characterization of mouse Gipc3. Int J Mol Med. 2002 Mar;9(3):251-6
  • Latest
    J:228590 La Torre A, et al., The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. Stem Cells. 2015 Sep;33(9):2674-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory