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Abcc10 Gene Detail
Summary
  • Symbol
    Abcc10
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
  • Synonyms
    Mrp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386976
    NCBI Gene: 224814
  • Gene Overview
    MyGene.info: ABCC10
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46303230-46328032 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386976
protein coding gene Chr17:46303221-46328352 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023812
protein coding gene Chr17:47351765-47374178 (-)
A/J MGP_AJ_G0023770
protein coding gene Chr17:46213242-46235730 (-)
AKR/J MGP_AKRJ_G0023741
protein coding gene Chr17:46553950-46578185 (-)
BALB/cJ MGP_BALBcJ_G0023774
protein coding gene Chr17:46116042-46140141 (-)
C3H/HeJ MGP_C3HHeJ_G0023538
protein coding gene Chr17:47282395-47311580 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024217
protein coding gene Chr17:49405222-49427449 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021667
protein coding gene Chr17:43016146-43040426 (-)
CAST/EiJ MGP_CASTEiJ_G0023019
protein coding gene Chr17:47406027-47427234 (-)
CBA/J MGP_CBAJ_G0023514
protein coding gene Chr17:51164758-51186447 (-)
DBA/2J MGP_DBA2J_G0023640
protein coding gene Chr17:45003049-45026844 (-)
FVB/NJ MGP_FVBNJ_G0023607
protein coding gene Chr17:44609329-44631437 (-)
LP/J MGP_LPJ_G0023721
protein coding gene Chr17:48029888-48055045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023636
protein coding gene Chr17:50729631-50755740 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024262
protein coding gene Chr17:46901370-46925996 (-)
PWK/PhJ MGP_PWKPhJ_G0022764
protein coding gene Chr17:44330335-44352044 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022579
protein coding gene Chr17:43802853-43826003 (-)
WSB/EiJ MGP_WSBEiJ_G0023084
protein coding gene Chr17:47452815-47476552 (-)



Homology
more
  • Human Ortholog
    ABCC10, ATP binding cassette subfamily C member 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABCC10, ATP binding cassette subfamily C member 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EST182763, MRP7, SIMRP7
  • Links
    NCBI Gene ID: 89845
    neXtProt AC: NX_Q5T3U5
    UniProt: Q5T3U5

  • Chr Location
    6p21.1; chr6:43427538-43451994 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 58616
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ABCC10
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homzozygous for a knock-out allele exhibit increased sensitivity to paclitaxel-induced mortality associated with weight loss, decreased white blood cell, and small spleen and thymus cortex due to apoptosis and/or depopulation of lymphoid cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224814 NCBI Gene Model | MGI Sequence Detail 24803 C57BL/6J ±  kb
    transcript NM_145140 RefSeq | MGI Sequence Detail 5472 C57BL/6  
    polypeptide Q8R4P9 UniProt | EBI | MGI Sequence Detail 1501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:76404 Kao H, et al., cDNA cloning and genomic organization of the murine MRP7, a new ATP-binding cassette transporter. Gene. 2002 Mar 20;286(2):299-306
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory