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Abcc10 Gene Detail
Summary
  • Symbol
    Abcc10
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
  • Synonyms
    Mrp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386976
    NCBI Gene: 224814
  • Gene Overview
    MyGene.info: ABCC10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:46303221-46328352 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25132 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ABCC10, ATP binding cassette subfamily C member 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABCC10, ATP binding cassette subfamily C member 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EST182763, MRP7, SIMRP7
  • Links
    NCBI Gene ID: 89845
    neXtProt AC: NX_Q5T3U5
    UniProt: Q5T3U5

  • Chr Location
    6p21.1; chr6:43427538-43451994 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 58616
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ABCC10
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homzozygous for a knock-out allele exhibit increased sensitivity to paclitaxel-induced mortality associated with weight loss, decreased white blood cell, and small spleen and thymus cortex due to apoptosis and/or depopulation of lymphoid cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036094 VEGA Gene Model | MGI Sequence Detail 25132 C57BL/6J ±  kb
    transcript OTTMUST00000092743 VEGA | MGI Sequence Detail 4885 Not Applicable  
    polypeptide OTTMUSP00000051324 VEGA | MGI Sequence Detail 1526 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      118 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:76404 Kao H, et al., cDNA cloning and genomic organization of the murine MRP7, a new ATP-binding cassette transporter. Gene. 2002 Mar 20;286(2):299-306
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory