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Mpp4
Gene Detail
Symbol

Name
ID
Mpp4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
MGI:2386681
Synonyms
DLG6
Feature Type
protein coding gene
Genetic Map
Chromosome 1
29.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:59120935-59163389 bp, - strand
From VEGA annotation of GRCm38

  42455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Mpp4

Human
homologs
Human Homolog MPP4, membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
NCBI Gene ID 58538
neXtProt AC  NX_Q96JB8
Human Synonyms  ALS2CR5, DLG6
Human Chr (Location)  2q33.2; chr2:201644874-201698694 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for mutations display sporadic photorecptor displacement. Correct protein localization at the presynaptic photoreceptor membrane.
 
Interactions
Mpp4 interacts with 86 markers (Mir22, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process protein localization to synapse
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (15)    Tissues (9)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000047223 (Evidence)
Ensembl Gene ModelENSMUSG00000079550 (Evidence)
Entrez Gene227157 (Evidence)
Consensus CDS ProjectCCDS48271.1, CCDS48272.1
International Mouse Knockout Project StatusMpp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047223 VEGA Gene Model | MGI Sequence Detail 42455 C57BL/6J ±  kb
transcript OTTMUST00000122110 VEGA | MGI Sequence Detail 2982 Not Applicable 
polypeptide OTTMUSP00000067080 VEGA | MGI Sequence Detail 654 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR004172 L27
InterPro IPR014775 L27, C-terminal
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000010545 MAGUK p55 subfamily member 4
References
(Earliest) J:78883 Inagaki H, et al., SPATIAL DISTRIBUTION OF mDLG6 mRNA IN EMBRYONIC AND ADULT MOUSE BRAIN. Cell Biol Int. 2002;26(7):635-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory