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Mpp4 Gene Detail
Summary
  • Symbol
    Mpp4
  • Name
    membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
  • Synonyms
    DLG6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386681
    NCBI Gene: 227157
Location & Maps
more
  • Sequence Map
    Chr1:59120935-59163389 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42455 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 29.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MPP4, membrane palmitoylated protein 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MPP4, membrane palmitoylated protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS2CR5, DLG6
  • Links
    NCBI Gene ID: 58538
    neXtProt AC: NX_Q96JB8

  • Chr Location
    2q33.2; chr2:201644874-201698834 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23296
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MPP4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Mpp4
  • Incidental Mutations
Homozygotes for mutations display sporadic photorecptor displacement. Correct protein localization at the presynaptic photoreceptor membrane.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047223 VEGA Gene Model | MGI Sequence Detail 42455 C57BL/6J ±  kb
transcript OTTMUST00000122110 VEGA | MGI Sequence Detail 2982 Not Applicable  
polypeptide OTTMUSP00000067080 VEGA | MGI Sequence Detail 654 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    380 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:78883 Inagaki H, et al., SPATIAL DISTRIBUTION OF mDLG6 mRNA IN EMBRYONIC AND ADULT MOUSE BRAIN. Cell Biol Int. 2002;26(7):635-40
  • Latest
    J:222615 Abe K, et al., The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. EMBO J. 2015 Jun 3;34(11):1523-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory