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Acmsd Gene Detail
Summary
  • Symbol
    Acmsd
  • Name
    amino carboxymuconate semialdehyde decarboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386323
    NCBI Gene: 266645
Location & Maps
more
  • Sequence Map
    Chr1:127729413-127767978 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38566 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    ACMSD, aminocarboxymuconate semialdehyde decarboxylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACMSD, aminocarboxymuconate semialdehyde decarboxylase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 130013
    neXtProt AC: NX_Q8TDX5

  • Chr Location
    2q21.3; chr2:134838348-134902076 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Acmsd
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049346 VEGA Gene Model | MGI Sequence Detail 38566 C57BL/6J ±  kb
transcript OTTMUST00000125793 VEGA | MGI Sequence Detail 2717 Not Applicable  
polypeptide OTTMUSP00000068098 VEGA | MGI Sequence Detail 336 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    214 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003629 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
  • EC
  • InterPro Domains
    IPR006680 Amidohydrolase-related
    IPR032465 Amino-carboxymuconate-semialdehyde decarboxylase
    IPR032466 Metal-dependent hydrolase
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:79121 Fukuoka S, et al., Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'. J Biol Chem. 2002 Sep 20;277(38):35162-7
  • Latest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory