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Pars2 Gene Detail
Summary
  • Symbol
    Pars2
  • Name
    prolyl-tRNA synthetase (mitochondrial)(putative)
  • Synonyms
    MGC:47008
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386296
    NCBI Gene: 230577
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:106651069-106655282 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 49.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386296
protein coding gene Chr4:106651022-106655282 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028523
protein coding gene Chr4:107288440-107292653 (+)
A/J MGP_AJ_G0028486
protein coding gene Chr4:103456223-103460436 (+)
AKR/J MGP_AKRJ_G0028433
protein coding gene Chr4:105969584-105973797 (+)
BALB/cJ MGP_BALBcJ_G0028505
protein coding gene Chr4:103644124-103648337 (+)
C3H/HeJ MGP_C3HHeJ_G0028219
protein coding gene Chr4:106723291-106727504 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028945
protein coding gene Chr4:111160347-111164560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026236
protein coding gene Chr4:98733102-98737275 (+)
CAST/EiJ MGP_CASTEiJ_G0027655
protein coding gene Chr4:104523281-104527471 (+)
CBA/J MGP_CBAJ_G0028188
protein coding gene Chr4:114747602-114751815 (+)
DBA/2J MGP_DBA2J_G0028336
protein coding gene Chr4:103073201-103077414 (+)
FVB/NJ MGP_FVBNJ_G0028304
protein coding gene Chr4:101928949-101933162 (+)
LP/J MGP_LPJ_G0028437
protein coding gene Chr4:107488621-107492834 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028330
protein coding gene Chr4:120071872-120076085 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028981
protein coding gene Chr4:106218578-106222791 (+)
PWK/PhJ MGP_PWKPhJ_G0027381
protein coding gene Chr4:101308929-101313142 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027205
protein coding gene Chr4:103599538-103603733 (+)
WSB/EiJ MGP_WSBEiJ_G0027736
protein coding gene Chr4:106390204-106394417 (+)



Homology
more
  • Human Ortholog
    PARS2, prolyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARS2, prolyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MT-PRORS, proRS
  • Links
    NCBI Gene ID: 25973
    neXtProt AC: NX_Q7L3T8
    UniProt: Q7L3T8

  • Chr Location
    1p32.3; chr1:54756898-54764553 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5830
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PARS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    2
  • Gene trapped
    31
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Pars2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043572 Ensembl Gene Model | MGI Sequence Detail 4214 C57BL/6J ±  kb
transcript ENSMUST00000106781 Ensembl | MGI Sequence Detail 3046 Not Applicable  
polypeptide ENSMUSP00000102393 Ensembl | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
    IPR004154 Anticodon-binding
    IPR036621 Anticodon-binding domain superfamily
    IPR033730 Prokaryote proline-tRNA ligase core domain
    IPR002316 Proline-tRNA ligase, class IIa
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory