Papln
Gene Detail

Symbol Name ID

Papln papilin, proteoglycan-like sulfated glycoprotein MGI:2386139

Synonyms

E030033C16Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 12

38.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:83763634-83792382 bp, + strand From VEGA annotation of GRCm38   28749 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:71541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Papln

Human homologs

Human Homolog		PAPLN, papilin, proteoglycan-like sulfated glycoprotein
NCBI Gene ID		89932
neXtProt AC		NX_O95428
Human Chr (Location)		14q24.2; chr14:73704205-73741348 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	negative regulation of peptidase activity
Component	basement membrane, extracellular matrix, ...
Function	metalloendopeptidase activity, metallopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (8)    Images (2)
Theiler Stages: 11, 17, 24

Assay Type	Results
Immunohistochemistry	3
RNA in situ	4
RT-PCR	1

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(1) cDNA(27) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000027564 (Evidence)
Ensembl Gene Model	ENSMUSG00000021223 (Evidence)
Entrez Gene	170721 (Evidence)
UniGene	133443
DFCI	TC1584147, TC1619974
DoTS	DT.524368, DT.91585963, DT.94258448
NIA Mouse Gene Index	U014176
Consensus CDS Project	CCDS26031.1, CCDS56847.1
International Mouse Knockout Project Status	Papln

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027564	VEGA Gene Model | MGI Sequence Detail	28749	C57BL/6J
transcript	OTTMUST00000068258	VEGA | MGI Sequence Detail	4373	Not Applicable
polypeptide	OTTMUSP00000034464	VEGA | MGI Sequence Detail	1302	Not Applicable

All sequences(36) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(165 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010294	ADAM-TS Spacer 1
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR013273	Peptidase M12B, ADAM-TS
InterPro	IPR010909	PLAC
InterPro	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site
InterPro	IPR002223	Proteinase inhibitor I2, Kunitz metazoa
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000012266	papilin

References

(Earliest) J:74708 Kramerova IA, et al., Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Development. 2000 Dec;127(24):5475-85
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Other accession IDs

MGI:2444137