Cerk MGI Mouse Gene Detail - MGI:2386052

Cerk Gene Detail

Symbol

Cerk
Name

ceramide kinase
Synonyms

D330016D08Rik, mKIAA1646

Feature Type

protein coding gene
IDs

MGI:2386052
NCBI Gene: 223753
Gene Overview

MyGene.info: CERK

Sequence Map

Chr15:86139128-86186141 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

47014 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.52 cM
Mapping Data

2 experiments

Human Ortholog

CERK, ceramide kinase

Vertebrate Orthologs

9

Human Ortholog

CERK, ceramide kinase
Orthology source: HomoloGene, HGNC
Synonyms

dA59H18.2, dA59H18.3, hCERK, LK4
Links

HGNC:19256

NCBI Gene ID: 64781

neXtProt AC: NX_Q8TCT0

UniProt: Q8TCT0
Chr Location

22q13.31; chr22:46684410-46738255 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11247
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CERK
Gene Tree

Cerk

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Cerk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.

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All GO Annotations

18
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

200
Tissues

170
cDNA Data

10
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cerk

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Cerk interacts with 249 markers (Mir15a, Mir17, Mir18, ...) View All

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All Sequences

46
RefSeq

6
UniProt

3
CCDS

CCDS27728.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023778	VEGA Gene Model \| MGI Sequence Detail	47014	C57BL/6J	± kb
transcript	OTTMUST00000058099	VEGA \| MGI Sequence Detail	4518	Not Applicable
polypeptide	OTTMUSP00000028102	VEGA \| MGI Sequence Detail	531	Not Applicable

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SNPs within 2kb

516 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000005363 ceramide kinase

(term hierarchy)
EC

2.7.1.138
InterPro Domains

IPR001206 Diacylglycerol kinase, catalytic domain

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1

IPR016064 NAD kinase/diacylglycerol kinase-like domain

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 4

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MGI:2146081, MGI:2443499

Summaries

All 61

Developmental Gene Expression 8

Diseases 1

Gene Ontology 6

Phenotypes 29
Earliest

J:13437 Bangham JW, Hairy ears, Eh. Mouse News Lett. 1965;33:68
Latest

J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/08/2017 MGI 6.10