Cerk
Gene Detail

Symbol

Name
ID

Cerk
ceramide kinase
MGI:2386052

Synonyms

D330016D08Rik, mKIAA1646

Feature Type

protein coding gene

Genetic Map

Chromosome 15
40.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:86139128-86186141 bp, - strand From VEGA annotation of GRCm38   47014 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:11247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cerk

Human
homologs

Human Homolog		CERK, ceramide kinase
NCBI Gene ID		64781
neXtProt AC		NX_Q8TCT0
Human Synonyms		dA59H18.2, dA59H18.3, hCERK, LK4
Human Chr (Location)		22q13.31; chr22:46684410-46738255 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Cerk (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.

 
Phenotype Images(2)

Interactions

Cerk interacts with 249 markers (Mir15a, Mir17, Mir18, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	ceramide metabolic process, lipid phosphorylation, ...
Component	cytoplasm, integral component of membrane, ...
Function	ATP binding, ceramide kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (200)    Tissues (170)    Images (33)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	167
Northern blot	12
RT-PCR	21

cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000023778 (Evidence)
Ensembl Gene Model	ENSMUSG00000035891 (Evidence)
Entrez Gene	223753 (Evidence)
DFCI	TC1576291
DoTS	DT.55202430, DT.94259196, DT.101185445, DT.91407754
NIA Mouse Gene Index	U036506
EC	2.7.1.138
Consensus CDS Project	CCDS27728.1
International Mouse Knockout Project Status	Cerk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023778	VEGA Gene Model | MGI Sequence Detail	47014	C57BL/6J
transcript	OTTMUST00000058099	VEGA | MGI Sequence Detail	4518	Not Applicable
polypeptide	OTTMUSP00000028102	VEGA | MGI Sequence Detail	531	Not Applicable

All sequences(50) RefSeq(4) UniProt(5)

Polymorphisms

SNPs within 2kb(519 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR016064	ATP-NAD kinase-like domain
InterPro	IPR001206	Diacylglycerol kinase, catalytic domain
Protein Ontology	PR:000005363	ceramide kinase

References

(Earliest) J:77669 Sugiura M, et al., Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem. 2002 Jun 28;277(26):23294-300
(Latest) J:214755 Wijesinghe DS, et al., Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts. J Lipid Res. 2014 May 13;55(7):1298-1309
All references(46)

Other
accession IDs

MGI:2146081, MGI:2443499