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Cerk Gene Detail
Summary
  • Symbol
    Cerk
  • Name
    ceramide kinase
  • Synonyms
    D330016D08Rik, mKIAA1646
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386052
    NCBI Gene: 223753
  • Gene Overview
    MyGene.info: CERK
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:86139128-86186141 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 40.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    516 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386052
protein coding gene Chr15:86139101-86186336 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022202
protein coding gene Chr15:87092352-87145332 (-)
A/J MGP_AJ_G0022161
protein coding gene Chr15:83820683-83870661 (-)
AKR/J MGP_AKRJ_G0022136
protein coding gene Chr15:86292009-86343174 (-)
BALB/cJ MGP_BALBcJ_G0022167
protein coding gene Chr15:83945683-83997333 (-)
C3H/HeJ MGP_C3HHeJ_G0021937
protein coding gene Chr15:86240718-86297327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022612
protein coding gene Chr15:90318956-90378130 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020137
protein coding gene Chr15:80129207-80171844 (-)
CAST/EiJ MGP_CASTEiJ_G0021459
protein coding gene Chr15:87063995-87121364 (-)
CBA/J MGP_CBAJ_G0021904
protein coding gene Chr15:93364376-93429566 (-)
DBA/2J MGP_DBA2J_G0022031
protein coding gene Chr15:83276616-83325129 (-)
FVB/NJ MGP_FVBNJ_G0022010
protein coding gene Chr15:82360886-82412059 (-)
LP/J MGP_LPJ_G0022102
protein coding gene Chr15:87237713-87292670 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022030
protein coding gene Chr15:97992905-98044259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022627
protein coding gene Chr15:86318167-86370141 (-)
PWK/PhJ MGP_PWKPhJ_G0021200
protein coding gene Chr15:83300080-83349886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021034
protein coding gene Chr15:86023087-86073733 (-)
WSB/EiJ MGP_WSBEiJ_G0021508
protein coding gene Chr15:86798122-86849619 (-)



Homology
more
  • Human Ortholog
    CERK, ceramide kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CERK, ceramide kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dA59H18.2, dA59H18.3, hCERK, LK4
  • Links
    NCBI Gene ID: 64781
    neXtProt AC: NX_Q8TCT0
    UniProt: Q8TCT0

  • Chr Location
    22q13.31; chr22:46684410-46738255 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11247
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CERK
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035891 Ensembl Gene Model | MGI Sequence Detail 47014 C57BL/6J ±  kb
    transcript ENSMUST00000044332 Ensembl | MGI Sequence Detail 4518 Not Applicable  
    polypeptide ENSMUSP00000038203 Ensembl | MGI Sequence Detail 531 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146081, MGI:2443499
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 6
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory