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Cerk Gene Detail
Summary
  • Symbol
    Cerk
  • Name
    ceramide kinase
  • Synonyms
    D330016D08Rik, mKIAA1646
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386052
    NCBI Gene: 223753
  • Gene Overview
    MyGene.info: CERK
Location & Maps
more
  • Sequence Map
    Chr15:86139128-86186141 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      47014 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CERK, ceramide kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CERK, ceramide kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dA59H18.2, dA59H18.3, hCERK, LK4
  • Links
    NCBI Gene ID: 64781
    neXtProt AC: NX_Q8TCT0

  • Chr Location
    22q13.31; chr22:46684410-46738255 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 11247
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CERK
  • Gene Tree
    Cerk
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Cerk
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    200
  • Tissues
    170
  • cDNA Data
    10
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023778 VEGA Gene Model | MGI Sequence Detail 47014 C57BL/6J ±  kb
transcript OTTMUST00000058099 VEGA | MGI Sequence Detail 4518 Not Applicable  
polypeptide OTTMUSP00000028102 VEGA | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    516 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005363 ceramide kinase
  • EC
    2.7.1.138
  • InterPro Domains
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR016064 NAD kinase/diacylglycerol kinase-like domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146081, MGI:2443499
References
more
  • Summaries
    All 42
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:77669 Sugiura M, et al., Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem. 2002 Jun 28;277(26):23294-300
  • Latest
    J:214755 Wijesinghe DS, et al., Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts. J Lipid Res. 2014 May 13;55(7):1298-1309
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory