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Cerk
Gene Detail
Symbol

Name
ID
Cerk
ceramide kinase
MGI:2386052
Synonyms
D330016D08Rik, mKIAA1646
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:86139128-86186141 bp, - strand
From VEGA annotation of GRCm38

  47014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cerk

Human
homologs
Human Homolog CERK, ceramide kinase
NCBI Gene ID 64781
neXtProt AC  NX_Q8TCT0
Human Synonyms  dA59H18.2, dA59H18.3, hCERK, LK4
Human Chr (Location)  22q13.31; chr22:46684410-46738255 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Cerk (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.
 
Interactions
Cerk interacts with 249 markers (Mir15a, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ceramide metabolic process, lipid phosphorylation, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, ceramide kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (200)    Tissues (169)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 167
Northern blot 12
RT-PCR 21
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023778 (Evidence)
Ensembl Gene ModelENSMUSG00000035891 (Evidence)
Entrez Gene223753 (Evidence)
DFCITC1576291
DoTSDT.94259196, DT.91407754, DT.55202430, DT.101185445
NIA Mouse Gene IndexU036506
EC2.7.1.138
Consensus CDS ProjectCCDS27728.1
International Mouse Knockout Project StatusCerk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023778 VEGA Gene Model | MGI Sequence Detail 47014 C57BL/6J ±  kb
transcript OTTMUST00000058099 VEGA | MGI Sequence Detail 4518 Not Applicable 
polypeptide OTTMUSP00000028102 VEGA | MGI Sequence Detail 531 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(519 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
Protein Ontology PR:000005363 ceramide kinase
References
(Earliest) J:77669 Sugiura M, et al., Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem. 2002 Jun 28;277(26):23294-300
(Latest) J:214755 Wijesinghe DS, et al., Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts. J Lipid Res. 2014 May 13;55(7):1298-1309
All references(46)
Other
accession IDs
MGI:2146081, MGI:2443499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory