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Cerk Gene Detail
Summary
  • Symbol
    Cerk
  • Name
    ceramide kinase
  • Synonyms
    D330016D08Rik, mKIAA1646
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386052
    NCBI Gene: 223753
  • Gene Overview
    MyGene.info: CERK
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:86139128-86186141 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      47014 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CERK, ceramide kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CERK, ceramide kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dA59H18.2, dA59H18.3, hCERK, LK4
  • Links
    NCBI Gene ID: 64781
    neXtProt AC: NX_Q8TCT0
    UniProt: Q8TCT0

  • Chr Location
    22q13.31; chr22:46684410-46738255 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 11247
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CERK
  • Gene Tree
    Cerk
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced body weight, increased susceptibility to infection and decreased neutrophil numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    200
  • Tissues
    170
  • cDNA Data
    10
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023778 VEGA Gene Model | MGI Sequence Detail 47014 C57BL/6J ±  kb
    transcript OTTMUST00000058099 VEGA | MGI Sequence Detail 4518 Not Applicable  
    polypeptide OTTMUSP00000028102 VEGA | MGI Sequence Detail 531 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      516 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146081, MGI:2443499
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 6
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory