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Gabbr2 Gene Detail
Summary
  • Symbol
    Gabbr2
  • Name
    gamma-aminobutyric acid (GABA) B receptor, 2
  • Synonyms
    Gababr2, GB2, Gpr51, LOC242425
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386030
    NCBI Gene: 242425
  • Gene Overview
    MyGene.info: GABBR2
Location & Maps
more
  • Sequence Map
    Chr4:46662305-46991873 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      329569 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GABBR2, gamma-aminobutyric acid type B receptor subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GABBR2, gamma-aminobutyric acid type B receptor subunit 2
    Orthology source: HomoloGene
  • Synonyms
    GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
  • Links
    NCBI Gene ID: 9568
    neXtProt AC: NX_O75899

  • Chr Location
    9q22.1-q22.3; chr9:98288082-98709197 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GABBR2 associations

Human Disease Mouse Models
       Tobacco Addiction, Susceptibility to   OMIM: 188890
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in clonic seizures, hyperactivity, hyperalgesia in response to thermal or mechanical stimuli, increased anxiety, and decreased depression-related behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006774 VEGA Gene Model | MGI Sequence Detail 329569 C57BL/6J ±  kb
transcript OTTMUST00000015583 VEGA | MGI Sequence Detail 5750 Not Applicable  
polypeptide OTTMUSP00000007177 VEGA | MGI Sequence Detail 940 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2020 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007762 gamma-aminobutyric acid type B receptor subunit 2
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR002455 GPCR family 3, GABA-B receptor
    IPR002456 GPCR family 3, gamma-aminobutyric acid receptor, type B1
    IPR002457 GPCR family 3, gamma-aminobutyric acid receptor, type B2
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
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MGI:2685271
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:77469 Davis AM, et al., Gamma-aminobutyric acidB receptors and the development of the ventromedial nucleus of the hypothalamus. J Comp Neurol. 2002 Jul 29;449(3):270-80
  • Latest
    J:219628 Hanack C, et al., GABA blocks pathological but not acute TRPV1 pain signals. Cell. 2015 Feb 12;160(4):759-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory