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Gabbr2
Gene Detail
 Symbol
Name
ID
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
MGI:2386030
Synonyms Gababr2, Gpr51, LOC242425
Feature Type protein coding gene
Genetic Map
Chromosome 4
25.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:46662318-46991873 bp, - strand
From VEGA annotation of GRCm38

  329556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55902  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: gamma-aminobutyric acid B receptor
Gene Tree: Gabbr2

Human
homologs
Human Homolog GABBR2, gamma-aminobutyric acid (GABA) B receptor, 2
NCBI Gene ID 9568
neXtProt AC  NX_O75899
Human Synonyms  GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Human Chr (Location)  9q22.1-q22.3; chr9:98288082-98709197 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GABBR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in clonic seizures, hyperactivity, hyperalgesia in response to thermal or mechanical stimuli, increased anxiety, and decreased depression-related behavior.
 
Interactions
Gabbr2 interacts with 368 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process gamma-aminobutyric acid signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cell junction, cytoplasm, ...
Function G-protein coupled GABA receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (17)    Tissues (11)    Images (6)
Theiler Stages: 19, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 8
RT-PCR 9
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000006774 (Evidence)
Ensembl Gene ModelENSMUSG00000039809 (Evidence)
Entrez Gene242425 (Evidence)
UniGene101909
DFCITC1636374
DoTSDT.101734833
NIA Mouse Gene IndexU025037
Consensus CDS ProjectCCDS38758.1
International Mouse Knockout Project StatusGabbr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006774 VEGA Gene Model | MGI Sequence Detail 329556 C57BL/6J ±  kb
transcript OTTMUST00000015583 VEGA | MGI Sequence Detail 5737 Not Applicable 
polypeptide OTTMUSP00000007177 VEGA | MGI Sequence Detail 940 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(2029 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2031)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR002455 GPCR, family 3, gamma-aminobutyric acid receptor, type B
InterPro IPR002457 GPCR, family 3, gamma-aminobutyric acid receptor, type B2
Protein Ontology PR:000007762 gamma-aminobutyric acid type B receptor subunit 2
References (Earliest) J:77469 Davis AM, et al., Gamma-aminobutyric acidB receptors and the development of the ventromedial nucleus of the hypothalamus. J Comp Neurol. 2002 Jul 29;449(3):270-80
(Latest) J:206310 Giachino C, et al., GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development. 2014 Jan;141(1):83-90
All references(40)
Other
accession IDs
MGI:2685271

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory