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C1qtnf5 Gene Detail
Summary
  • Symbol
    C1qtnf5
  • Name
    C1q and tumor necrosis factor related protein 5
  • Synonyms
    CTRP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385958
    NCBI Gene: 235312
  • Gene Overview
    MyGene.info: C1QTNF5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44107245-44109187 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385958
protein coding gene Chr9:44101770-44109187 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034692
protein coding gene Chr9:42561180-42563122 (+)
A/J MGP_AJ_G0034672
protein coding gene Chr9:41392877-41394819 (+)
AKR/J MGP_AKRJ_G0034598
protein coding gene Chr9:42250063-42252005 (+)
BALB/cJ MGP_BALBcJ_G0034663
protein coding gene Chr9:41132883-41134825 (+)
C3H/HeJ MGP_C3HHeJ_G0034374
protein coding gene Chr9:42703772-42705714 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035185
protein coding gene Chr9:43839580-43841522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032099
protein coding gene Chr9:40983578-40985515 (+)
CAST/EiJ MGP_CASTEiJ_G0033697
protein coding gene Chr9:42545580-42547522 (+)
CBA/J MGP_CBAJ_G0034347
protein coding gene Chr9:45417570-45419512 (+)
DBA/2J MGP_DBA2J_G0034506
protein coding gene Chr9:41305946-41307888 (+)
FVB/NJ MGP_FVBNJ_G0034446
protein coding gene Chr9:40555091-40557033 (+)
LP/J MGP_LPJ_G0034587
protein coding gene Chr9:42864258-42866200 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034490
protein coding gene Chr9:47295545-47297487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035205
protein coding gene Chr9:42144672-42146614 (+)
PWK/PhJ MGP_PWKPhJ_G0033402
protein coding gene Chr9:41172090-41174034 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033237
protein coding gene Chr9:42445020-42446961 (+)
WSB/EiJ MGP_WSBEiJ_G0033810
protein coding gene Chr9:42182326-42184268 (+)



Homology
more
  • Human Ortholog
    C1QTNF5, C1q and TNF related 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C1QTNF5, C1q and TNF related 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRP5, MFRP
  • Links
    NCBI Gene ID: 114902
    neXtProt AC: NX_Q9BXJ0
    UniProt: Q9BXJ0

  • Chr Location
    11q23.3; chr11:119338934-119346673 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with C1qtnf5 mouse models; 1 with human C1QTNF5 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Heterozygotes for a knock-in mutation show features of late-onset retinal degeneration, whereas hetero- or homozygotes for the same knock-in generated by a different group lack retinal defects. Homozygous null mice exhibit reduced hepatic steatosis and improved insulin action on a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079592 Ensembl Gene Model | MGI Sequence Detail 1943 C57BL/6J ±  kb
    transcript ENSMUST00000114815 Ensembl | MGI Sequence Detail 1215 Not Applicable  
    polypeptide ENSMUSP00000110463 Ensembl | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:78123 Kameya S, et al., Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Hum Mol Genet. 2002 Aug 1;11(16):1879-86
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory