Mfrp
Gene Detail

Symbol Name ID

Mfrp membrane-type frizzled-related protein MGI:2385957

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:44101738-44109187 bp, + strand From VEGA annotation of GRCm38   7450 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: Mfrp

Human homologs

Human Homolog		MFRP, membrane frizzled-related protein
NCBI Gene ID		83552
neXtProt AC		NX_Q9BXJ0, NX_Q9BY79
Human Synonyms		MCOP5, NNO2, RD6
Human Chr (Location)		11q23; chr11:119209652-119217383 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MFRP

Alleles and phenotypes

All alleles(2) : Spontaneous(2)
 

Mutations produce mice having small, white retinal spots and progressive photoreceptor degeneration.

 
Human Diseases Modeled Using Mouse Mfrp (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process

eye photoreceptor cell development, retina development in camera-type eye, ...

External Resources: FuncBase

Expression

cDNA source data(1)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(1) Other(2)

Other database links

VEGA Gene Model	OTTMUSG00000033669 (Evidence)
Ensembl Gene Model	ENSMUSG00000034739 (Evidence)
Entrez Gene	259172 (Evidence)
Consensus CDS Project	CCDS40597.1, CCDS52776.1
International Mouse Knockout Project Status	Mfrp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033669	VEGA Gene Model | MGI Sequence Detail	7450	C57BL/6J
transcript	OTTMUST00000084831	VEGA | MGI Sequence Detail	4203	Not Applicable
polypeptide	OTTMUSP00000045762	VEGA | MGI Sequence Detail	584	Not Applicable

All sequences(23) RefSeq(4)

Polymorphisms

SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000010372	membrane frizzled-related protein

References

(Earliest) J:64087 Hawes NL, et al., Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3149-57
(Latest) J:181596 Fogerty J, et al., 174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy. Invest Ophthalmol Vis Sci. 2011 Sep;52(10):7256-66
All references(19)

Other accession IDs

MGI:1888693