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Mfrp
Gene Detail
Symbol

Name
ID
Mfrp
membrane-type frizzled-related protein
MGI:2385957
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:44101738-44109187 bp, + strand
From VEGA annotation of GRCm38

  7450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12866  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement subcomponent C1q chain A
Gene Tree: Mfrp

Human
homologs
Human Homolog MFRP, membrane frizzled-related protein
NCBI Gene ID 83552
neXtProt AC  NX_Q9BY79
Human Synonyms  MCOP5, NNO2, RD6
Human Chr (Location)  11q23; chr11:119338934-119346673 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human MFRP
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations produce mice having small, white retinal spots and progressive photoreceptor degeneration.
 
Human Diseases Modeled Using Mouse Mfrp (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Mfrp interacts with 186 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process eye photoreceptor cell development, retina development in camera-type eye, ...
External Resources: FuncBase
Expression
cDNA source data(1)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(1) Other(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033669 (Evidence)
Ensembl Gene ModelENSMUSG00000034739 (Evidence)
Entrez Gene259172 (Evidence)
Consensus CDS ProjectCCDS40597.1, CCDS52776.1
International Mouse Knockout Project StatusMfrp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033669 VEGA Gene Model | MGI Sequence Detail 7450 C57BL/6J ±  kb
transcript OTTMUST00000084831 VEGA | MGI Sequence Detail 4203 Not Applicable 
polypeptide OTTMUSP00000045762 VEGA | MGI Sequence Detail 584 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010372 membrane frizzled-related protein
References
(Earliest) J:64087 Hawes NL, et al., Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3149-57
(Latest) J:202093 Won J, et al., Genetic modifier loci of mouse Mfrp identified by quantitative trait locus analysis. Exp Eye Res. 2013 Nov 4;
All references(21)
Disease annotation references (1)
Other
accession IDs
MGI:1888693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory