About   Help   FAQ
Mfrp Gene Detail
Summary
  • Symbol
    Mfrp
  • Name
    membrane frizzled-related protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385957
    NCBI Gene: 259172
  • Gene Overview
    MyGene.info: MFRP
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44101770-44109187 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385957
protein coding gene Chr9:44101729-44109187 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034691
protein coding gene Chr9:42555661-42563122 (+)
A/J MGP_AJ_G0034671
protein coding gene Chr9:41387361-41394819 (+)
AKR/J MGP_AKRJ_G0034597
protein coding gene Chr9:42244544-42252005 (+)
BALB/cJ MGP_BALBcJ_G0034662
protein coding gene Chr9:41127379-41134825 (+)
C3H/HeJ MGP_C3HHeJ_G0034373
protein coding gene Chr9:42696820-42705714 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035184
protein coding gene Chr9:43834037-43841522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032098
protein coding gene Chr9:40978067-40985515 (+)
CAST/EiJ MGP_CASTEiJ_G0033696
protein coding gene Chr9:42540073-42547522 (+)
CBA/J MGP_CBAJ_G0034346
protein coding gene Chr9:45412062-45419512 (+)
DBA/2J MGP_DBA2J_G0034505
protein coding gene Chr9:41300423-41307888 (+)
FVB/NJ MGP_FVBNJ_G0034445
protein coding gene Chr9:40549572-40557033 (+)
LP/J MGP_LPJ_G0034586
protein coding gene Chr9:42858739-42866200 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034489
protein coding gene Chr9:47290017-47297487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035204
protein coding gene Chr9:42139172-42146614 (+)
PWK/PhJ MGP_PWKPhJ_G0033401
protein coding gene Chr9:41166595-41174034 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033236
protein coding gene Chr9:42439486-42446961 (+)
WSB/EiJ MGP_WSBEiJ_G0033809
protein coding gene Chr9:42176773-42184268 (+)



Homology
more
  • Human Ortholog
    MFRP, membrane frizzled-related protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MFRP, membrane frizzled-related protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRP5, MCOP5, NNO2, RD6
  • Links
    NCBI Gene ID: 83552
    neXtProt AC: NX_Q9BY79
    UniProt: Q9BY79

  • Chr Location
    11q23.3; chr11:119338934-119346673 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mfrp mouse models; 1 with human MFRP associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations produce mice having small, white retinal spots and progressive photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 259172 NCBI Gene Model | MGI Sequence Detail 7418 C57BL/6J ±  kb
transcript NM_147126 RefSeq | MGI Sequence Detail 4292 C57BL/6  
polypeptide NP_667337 RefSeq | MGI Sequence Detail 584 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2
Other
Accession IDs
less
MGI:1888693
References
more
  • Summaries
    All 21
    Diseases 1
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:64087 Hawes NL, et al., Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3149-57
  • Latest
    J:223089 Soundararajan R, et al., Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs. PLoS One. 2014;9(10):e110299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory