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Defb19 Gene Detail
Summary
  • Symbol
    Defb19
  • Name
    defensin beta 19
  • Synonyms
    Tdl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385955
    NCBI Gene: 246700
  • Gene Overview
    MyGene.info: DEFB119
Location & Maps
more
  • Sequence Map
    Chr2:152576086-152580312 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4227 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.31 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DEFB119, defensin beta 119
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DEFB119, defensin beta 119
    Orthology source: HomoloGene
  • Synonyms
    DEFB120, DEFB-19, DEFB20, DEFB-20, ESC42-RELA, ESC42-RELB
  • Links
    NCBI Gene ID: 245932
    neXtProt AC: NX_Q8N690

  • Chr Location
    20q11.21; chr20:31377163-31390649 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Defb19
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015831 VEGA Gene Model | MGI Sequence Detail 4227 C57BL/6J ±  kb
transcript OTTMUST00000037637 VEGA | MGI Sequence Detail 394 Not Applicable  
polypeptide OTTMUSP00000016873 VEGA | MGI Sequence Detail 83 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:78164 Yamamoto M, et al., Testis-specific expression of a novel mouse defensin-like gene, Tdl. Mech Dev. 2002 Aug;116(1-2):217-21
  • Latest
    J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory