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Defb19 Gene Detail
Summary
  • Symbol
    Defb19
  • Name
    defensin beta 19
  • Synonyms
    Tdl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385955
    NCBI Gene: 246700
  • Gene Overview
    MyGene.info: DEFB119
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152576086-152580312 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385955
protein coding gene Chr2:152576086-152580312 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026669
protein coding gene Chr2:157139557-157143627 (-)
A/J MGP_AJ_G0026635
protein coding gene Chr2:150864814-150869812 (-)
AKR/J MGP_AKRJ_G0026605
protein coding gene Chr2:155269985-155274210 (-)
BALB/cJ MGP_BALBcJ_G0026644
protein coding gene Chr2:151175856-151180014 (-)
C3H/HeJ MGP_C3HHeJ_G0026387
protein coding gene Chr2:155652115-155656939 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027093
protein coding gene Chr2:161710441-161714487 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024464
protein coding gene Chr2:144458892-144463146 (-)
CAST/EiJ MGP_CASTEiJ_G0025848
protein coding gene Chr2:155896215-155901914 (-)
CBA/J MGP_CBAJ_G0026365
protein coding gene Chr2:167641905-167646109 (-)
DBA/2J MGP_DBA2J_G0026501
protein coding gene Chr2:150079492-150084193 (-)
FVB/NJ MGP_FVBNJ_G0026467
protein coding gene Chr2:148534465-148538610 (-)
LP/J MGP_LPJ_G0026605
protein coding gene Chr2:157289840-157293967 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026488
protein coding gene Chr2:171749984-171754404 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027149
protein coding gene Chr2:155155830-155160857 (-)
PWK/PhJ MGP_PWKPhJ_G0025582
protein coding gene Chr2:149601196-149605764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025385
protein coding gene Chr2:154004345-154008588 (-)
WSB/EiJ MGP_WSBEiJ_G0025918
protein coding gene Chr2:156071831-156076054 (-)



Homology
more
  • Human Ortholog
    DEFB119, defensin beta 119
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DEFB119, defensin beta 119
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DEFB120, DEFB-19, DEFB20, DEFB-20, ESC42-RELA, ESC42-RELB
  • Links
    NCBI Gene ID: 245932
    neXtProt AC: NX_Q8N690
    UniProt: Q8N690

  • Chr Location
    20q11.21; chr20:31377163-31390649 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246700 NCBI Gene Model | MGI Sequence Detail 4227 C57BL/6J ±  kb
transcript NM_145157 RefSeq | MGI Sequence Detail 414 C57BL/6  
polypeptide Q8K3I8 UniProt | EBI | MGI Sequence Detail 83 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory