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Ces2c Gene Detail
Summary
  • Symbol
    Ces2c
  • Name
    carboxylesterase 2C
  • Synonyms
    Ces2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385905
    NCBI Gene: 234671
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105573700-105581115 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385905
 protein coding gene Chr8:105573700-105581115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034020
 protein coding gene Chr8:107003332-107027383 (+)
A/J MGP_AJ_G0034001
 protein coding gene Chr8:102763795-102813994 (+)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0031456
 protein coding gene Chr8:96004480-96032794 (+)
CAST/EiJ MGP_CASTEiJ_G0033033
 protein coding gene Chr8:106009708-106043329 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0033925
 protein coding gene Chr8:107197261-107238859 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033823
 protein coding gene Chr8:117797273-117846148 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034532
 protein coding gene Chr8:105700732-105716809 (+)
PWK/PhJ MGP_PWKPhJ_G0032734
 protein coding gene Chr8:101544983-101576115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032573
 protein coding gene Chr8:104477584-104490625 (+)
WSB/EiJ MGP_WSBEiJ_G0033148
 protein coding gene Chr8:106386875-106395970 (+)



Homology
more
  • Human Ortholog
    CES2, carboxylesterase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES2, carboxylesterase 2
  • Synonyms
    CE-2, CES2A1, iCE, PCE-2
  • Links
    NCBI Gene ID: 8824
    neXtProt AC: NX_O00748
    UniProt: O00748

  • Chr Location
    16q22.1; chr16:66934444-66945096 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234671 NCBI Gene Model | MGI Sequence Detail 7416 C57BL/6J ±  kb
    transcript NM_145603 RefSeq | MGI Sequence Detail 1978 C57BL/6  
    polypeptide Q91WG0 UniProt | EBI | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 3
    • Earliest
      J:184961 Furihata T, et al., Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family. Arch Biochem Biophys. 2003 Aug 1;416(1):101-9
    • Latest
      J:274133 Maresch LK, et al., Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity. Hepatol Commun. 2019 Feb;3(2):227-245
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory