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Tifab Gene Detail
Summary
  • Symbol
    Tifab
  • Name
    TRAF-interacting protein with forkhead-associated domain, family member B
  • Synonyms
    MGC:32345, MGC:37193
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385852
    NCBI Gene: 212937
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56173704-56178885 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385852
protein coding gene Chr13:56173703-56179013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020614
protein coding gene Chr13:55703942-55709082 (-)
A/J MGP_AJ_G0020568
protein coding gene Chr13:53638529-53643695 (-)
AKR/J MGP_AKRJ_G0020546
protein coding gene Chr13:55228313-55233495 (-)
BALB/cJ MGP_BALBcJ_G0020564
protein coding gene Chr13:53870635-53875800 (-)
C3H/HeJ MGP_C3HHeJ_G0020363
protein coding gene Chr13:55036004-55041166 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020998
protein coding gene Chr13:57397488-57402674 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018580
protein coding gene Chr13:51571842-51577236 (-)
CAST/EiJ MGP_CASTEiJ_G0019877
protein coding gene Chr13:55149125-55154238 (-)
CBA/J MGP_CBAJ_G0020323
protein coding gene Chr13:59592699-59597861 (-)
DBA/2J MGP_DBA2J_G0020446
protein coding gene Chr13:53187720-53192902 (-)
FVB/NJ MGP_FVBNJ_G0020425
protein coding gene Chr13:52653814-52658997 (-)
LP/J MGP_LPJ_G0020522
protein coding gene Chr13:55961528-55966709 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020454
protein coding gene Chr13:59010858-59016039 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021041
protein coding gene Chr13:54811878-54817060 (-)
PWK/PhJ MGP_PWKPhJ_G0019633
protein coding gene Chr13:53216594-53221824 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019460
protein coding gene Chr13:53743321-53748463 (-)
WSB/EiJ MGP_WSBEiJ_G0019939
protein coding gene Chr13:55176629-55181791 (-)



Homology
more
  • Human Ortholog
    TIFAB, TIFA inhibitor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TIFAB, TIFA inhibitor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 497189
    neXtProt AC: NX_Q6ZNK6
    UniProt: Q6ZNK6

  • Chr Location
    5q31.1; chr5:135448868-135452399 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049625 Ensembl Gene Model | MGI Sequence Detail 5182 C57BL/6J ±  kb
transcript ENSMUST00000169652 Ensembl | MGI Sequence Detail 3349 Not Applicable  
polypeptide ENSMUSP00000131162 Ensembl | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003287 TRAF-interacting protein with FHA domain-containing protein B
  • InterPro Domains
    IPR000253 Forkhead-associated (FHA) domain
    IPR008984 SMAD/FHA domain superfamily
    IPR033621 TRAF-interacting protein with FHA domain-containing protein
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:239424 Varney ME, et al., Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome. Leukemia. 2017 Feb;31(2):491-495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory