Bcas3 MGI Mouse Gene Detail - MGI:2385848 - breast carcinoma amplified sequence 3

Symbol

Bcas3
Name

breast carcinoma amplified sequence 3
Synonyms

1500019F07Rik, 2610028P08Rik, K20D4, rudhira

Feature Type

protein coding gene
IDs

MGI:2385848
NCBI Gene: 192197
Gene Overview

MyGene.info: BCAS3
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:85353167-85826058 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.34 cM
Mapping Data

3 experiments

SNPs within 2kb

2422 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385848	protein coding gene	Chr11:85353113-85826058 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018882	protein coding gene	Chr11:86855449-87357324 (+)
A/J	MGP_AJ_G0018849	protein coding gene	Chr11:83523396-83998967 (+)
AKR/J	MGP_AKRJ_G0018819	protein coding gene	Chr11:86023011-86513576 (+)
BALB/cJ	MGP_BALBcJ_G0018822	protein coding gene	Chr11:83907280-84382804 (+)
C3H/HeJ	MGP_C3HHeJ_G0018636	protein coding gene	Chr11:86051389-86537520 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019274	protein coding gene	Chr11:89497209-90009220 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016907	protein coding gene	Chr11:80569812-81039891 (+)
CAST/EiJ	MGP_CASTEiJ_G0018191	protein coding gene	Chr11:86699671-87193817 (+)
CBA/J	MGP_CBAJ_G0018607	protein coding gene	Chr11:93298219-93803656 (+)
DBA/2J	MGP_DBA2J_G0018715	protein coding gene	Chr11:83096350-83571816 (+)
FVB/NJ	MGP_FVBNJ_G0018704	protein coding gene	Chr11:82596605-83071003 (+)
LP/J	MGP_LPJ_G0018785	protein coding gene	Chr11:87364428-87852927 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018731	protein coding gene	Chr11:93420192-93923727 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019314	protein coding gene	Chr11:86268542-86756037 (+)
PWK/PhJ	MGP_PWKPhJ_G0017960	protein coding gene	Chr11:83871831-84354376 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017752	protein coding gene	Chr11:85819676-86299998 (+)
WSB/EiJ	MGP_WSBEiJ_G0018242	protein coding gene	Chr11:86119695-86609654 (+)

Human Ortholog

BCAS3, BCAS3, microtubule associated cell migration factor

Vertebrate Orthologs

10

Human Ortholog

BCAS3, BCAS3, microtubule associated cell migration factor
Orthology source: HomoloGene, HGNC
Synonyms

GAOB1, MAAB
Links

HGNC:14347

NCBI Gene ID: 54828

neXtProt AC: NX_Q9H6U6

UniProt: Q9H6U6
Chr Location

17q23.2; chr17:60677811-61392838 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9778
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: BCAS3
Gene Tree

Bcas3

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Phenotype Summary

26 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

1
Gene trapped

51
Targeted

3
Genomic Mutations

2 involving Bcas3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele or a conditional allele activated in endothelial cells exhibit embryonic lethality with abnormal development and cardiovascular patterning.

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All GO Annotations

37
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

83
Tissues

37
cDNA Data

97
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcas3

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Bcas3 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

114
RefSeq

27
UniProt

10
CCDS

CCDS25195.1, CCDS48873.1
UniGene

287663

Ensembl

ENSMUSG00000059439 (Evidence)
NCBI Gene

192197

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059439	Ensembl Gene Model \| MGI Sequence Detail	472892	C57BL/6J	± kb
transcript	ENSMUST00000108061	Ensembl \| MGI Sequence Detail	3810	Not Applicable
polypeptide	ENSMUSP00000103696	Ensembl \| MGI Sequence Detail	943	Not Applicable

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UniProt

10 Sequences
InterPro Domains

IPR022175 BCAS3 domain

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 99

cDNA 97

Primer pair 2

Microarray probesets 6

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MGI:1917451, MGI:1923594, MGI:2144406

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:262744 Shetty R, et al., Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Sci Rep. 2018 Apr 4;8(1):5632

TSS for Bcas3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103833	Chr11:85352775-85352797 (+)	-381 bp
Tssr103834	Chr11:85353156-85353219 (+)	21 bp
Tssr103835	Chr11:85492720-85492732 (+)	139,559 bp
Tssr103836	Chr11:85492737-85492751 (+)	139,577 bp
Tssr103846	Chr11:85821843-85821852 (+)	468,681 bp
Tssr103847	Chr11:85821857-85821865 (+)	468,694 bp
Tssr103848	Chr11:85821878-85821893 (+)	468,719 bp
Tssr103849	Chr11:85821909-85821949 (+)	468,762 bp
Tssr103850	Chr11:85821951-85821958 (+)	468,788 bp
Tssr103851	Chr11:85821961-85821968 (+)	468,798 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/15/2019 MGI 6.13