Bcas3
Gene Detail

Symbol

Name
ID

Bcas3
breast carcinoma amplified sequence 3
MGI:2385848

Synonyms

1500019F07Rik, 2610028P08Rik, K20D4, rudhira

Feature Type

protein coding gene

Genetic Map

Chromosome 11
51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:85353167-85826058 bp, + strand From VEGA annotation of GRCm38   472892 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:9778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bcas3

Human
homologs

Human Homolog		BCAS3, breast carcinoma amplified sequence 3
NCBI Gene ID		54828
neXtProt AC		NX_Q9H6U6
Human Synonyms		GAOB1, MAAB
Human Chr (Location)		17q23; chr17:60677811-61392838 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(52) : Gene trapped(51) Targeted(1)
Genomic Mutations involving Bcas3 (1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Bcas3 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (36 annotations)

Process	activation of Cdc42 GTPase activity, angiogenesis, ...
Component	cell leading edge, cell periphery, ...
Function	acetyltransferase activator activity, beta-tubulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (83)    Tissues (37)    Images (30)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	18
RNA in situ	29
RT-PCR	36

cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(98) cDNA(96) Primer pair(2)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000001026 (Evidence)
Ensembl Gene Model	ENSMUSG00000059439 (Evidence)
Entrez Gene	192197 (Evidence)
UniGene	287663
DFCI	TC1599600, TC1591659, TC1575651, TC1686574, TC1639324, TC1630610, TC1630934
DoTS	DT.101366697, DT.94290885, DT.40145677, DT.530548, DT.524620, DT.101400029, DT.110519137, DT.40136642
NIA Mouse Gene Index	U013121
Consensus CDS Project	CCDS25195.1, CCDS48873.1
International Mouse Knockout Project Status	Bcas3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001026	VEGA Gene Model | MGI Sequence Detail	472892	C57BL/6J
transcript	OTTMUST00000002042	VEGA | MGI Sequence Detail	3810	Not Applicable
polypeptide	OTTMUSP00000000985	VEGA | MGI Sequence Detail	943	Not Applicable

All sequences(138) RefSeq(21) UniProt(19)

Polymorphisms

SNPs within 2kb(2433 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR022175	Breast carcinoma amplified sequence 3
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000004680	breast carcinoma-amplified sequence 3

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:212786 Jain M, et al., Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. Exp Cell Res. 2012 Apr 1;318(6):753-67
All references(41)

Other
accession IDs

MGI:1917451, MGI:1923594, MGI:2144406