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Bcas3 Gene Detail
Summary
  • Symbol
    Bcas3
  • Name
    breast carcinoma amplified sequence 3
  • Synonyms
    1500019F07Rik, 2610028P08Rik, K20D4, rudhira
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385848
    NCBI Gene: 192197
  • Gene Overview
    MyGene.info: BCAS3
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:85353167-85826058 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385848
 protein coding gene Chr11:85353110-85826058 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018882
 protein coding gene Chr11:86855449-87357324 (+)
A/J MGP_AJ_G0018849
 protein coding gene Chr11:83523396-83998967 (+)
AKR/J MGP_AKRJ_G0018819
 protein coding gene Chr11:86023011-86513576 (+)
BALB/cJ MGP_BALBcJ_G0018822
 protein coding gene Chr11:83907280-84382804 (+)
C3H/HeJ MGP_C3HHeJ_G0018636
 protein coding gene Chr11:86051389-86537520 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019274
 protein coding gene Chr11:89497209-90009220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016907
 protein coding gene Chr11:80569812-81039891 (+)
CAST/EiJ MGP_CASTEiJ_G0018191
 protein coding gene Chr11:86699671-87193817 (+)
CBA/J MGP_CBAJ_G0018607
 protein coding gene Chr11:93298219-93803656 (+)
DBA/2J MGP_DBA2J_G0018715
 protein coding gene Chr11:83096350-83571816 (+)
FVB/NJ MGP_FVBNJ_G0018704
 protein coding gene Chr11:82596605-83071003 (+)
LP/J MGP_LPJ_G0018785
 protein coding gene Chr11:87364428-87852927 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018731
 protein coding gene Chr11:93420192-93923727 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019314
 protein coding gene Chr11:86268542-86756037 (+)
PWK/PhJ MGP_PWKPhJ_G0017960
 protein coding gene Chr11:83871831-84354376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017752
 protein coding gene Chr11:85819676-86299998 (+)
WSB/EiJ MGP_WSBEiJ_G0018242
 protein coding gene Chr11:86119695-86609654 (+)



Homology
more
  • Human Ortholog
    BCAS3, BCAS3 microtubule associated cell migration factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCAS3, BCAS3 microtubule associated cell migration factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAOB1, MAAB
  • Links
    NCBI Gene ID: 54828
    neXtProt AC: NX_Q9H6U6
    UniProt: Q9H6U6

  • Chr Location
    17q23.2; chr17:60677811-61392838 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9778
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BCAS3
  • Gene Tree
    Bcas3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or a conditional allele activated in endothelial cells exhibit embryonic lethality with abnormal development and cardiovascular patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    37
  • cDNA Data
    97
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059439 Ensembl Gene Model | MGI Sequence Detail 472892 C57BL/6J ±  kb
    transcript ENSMUST00000108061 Ensembl | MGI Sequence Detail 3810 Not Applicable  
    polypeptide ENSMUSP00000103696 Ensembl | MGI Sequence Detail 943 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 97
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917451, MGI:1923594, MGI:2144406
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262744 Shetty R, et al., Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Sci Rep. 2018 Apr 4;8(1):5632
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/31/2020
    MGI 6.15     		The Jackson Laboratory