Plekhb2 Gene Detail

Summary

• Symbol
  Plekhb2
• Name
  pleckstrin homology domain containing, family B (evectins) member 2
• Synonyms
  2310009M15Rik, evt-2, Phdc

• Feature Type
  protein coding gene
• IDs
  MGI:2385825
  NCBI Gene: 226971
• Gene Overview
  MyGene.info: PLEKHB2
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr1:34849976-34879580 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 13.34 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  174 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385825	protein coding gene	Chr1:34849941-34879585 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015916	protein coding gene	Chr1:33284814-33320481 (+)
A/J	MGP_AJ_G0015900	protein coding gene	Chr1:32448862-32478927 (+)
AKR/J	MGP_AKRJ_G0015855	protein coding gene	Chr1:32859226-32890638 (+)
BALB/cJ	MGP_BALBcJ_G0015854	protein coding gene	Chr1:32122022-32151706 (+)
C3H/HeJ	MGP_C3HHeJ_G0015687	protein coding gene	Chr1:33069423-33099153 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016307	protein coding gene	Chr1:34789370-34821300 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014029	protein coding gene	Chr1:29584484-29618707 (+)
CAST/EiJ	MGP_CASTEiJ_G0015268	protein coding gene	Chr1:32954176-32991825 (+)
CBA/J	MGP_CBAJ_G0015659	protein coding gene	Chr1:35731811-35761236 (+)
DBA/2J	MGP_DBA2J_G0015760	protein coding gene	Chr1:31803405-31833480 (+)
FVB/NJ	MGP_FVBNJ_G0015762	protein coding gene	Chr1:31333434-31364028 (+)
LP/J	MGP_LPJ_G0015830	protein coding gene	Chr1:33637563-33673565 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015782	protein coding gene	Chr1:37988582-38018095 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016354	protein coding gene	Chr1:32870511-32901924 (+)
PWK/PhJ	MGP_PWKPhJ_G0015051	protein coding gene	Chr1:31533549-31564727 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014833	protein coding gene	Chr1:32848623-32889077 (+)
WSB/EiJ	MGP_WSBEiJ_G0015330	protein coding gene	Chr1:32849109-32880085 (+)

Homology

• Human Ortholog
  PLEKHB2, pleckstrin homology domain containing B2

• Vertebrate Orthologs
  9

• Human Ortholog
  PLEKHB2, pleckstrin homology domain containing B2
  Orthology source: HomoloGene, HGNC
• Synonyms
  EVT2
• Links
  HGNC:19236

  NCBI Gene ID: 55041

  neXtProt AC: NX_Q96CS7

  UniProt: Q96CS7

  
  
• Chr Location
  2q21.1; chr2:131104847-131149852 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 9938
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: PLEKHB2
• Gene Tree
  Plekhb2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  22
• Chemically induced (other)
  1
• Gene trapped
  21
• Genomic Mutations
  1 involving Plekhb2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  24 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  5
• GO References
  3

• External Resources
  FuncBase

Expression

• cDNA Data
  185

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase plekhb2
  ZFIN plekhb2

Interactions

• Plekhb2 interacts with 277 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  61
• RefSeq
  8
• UniProt
  3
• CCDS
  CCDS14874.1, CCDS78558.1
• UniGene
  292751

• Ensembl
  ENSMUSG00000026123 (Evidence)
• NCBI Gene
  226971

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000026123	Ensembl Gene Model | MGI Sequence Detail	29605	C57BL/6J
transcript	ENSMUST00000027297	Ensembl | MGI Sequence Detail	3279	Not Applicable
polypeptide	ENSMUSP00000027297	Ensembl | MGI Sequence Detail	221	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000030549 pleckstrin homology domain-containing family B member 2
  (term hierarchy)
• PDB
  2DHI
• InterPro Domains
  IPR011993 PH-like domain superfamily
  IPR001849 Pleckstrin homology domain
  IPR039680 Pleckstrin homology domain-containing family B member 1/2
  IPR039815 Pleckstrin homology domain-containing family B member 2

Molecular
Reagents

• All nucleic 185

  cDNA 185

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1924835, MGI:2138415

References

• Summaries
  All 31

  Gene Ontology 3

  Phenotypes 5
• Earliest
  J:78057 Krappa R, et al., Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4633-8
• Latest
  J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Plekhb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6235	Chr1:34849694-34849720 (+)	-269 bp
Tssr6236	Chr1:34849937-34849947 (+)	-34 bp
Tssr6237	Chr1:34849950-34850010 (+)	4 bp
Tssr6238	Chr1:34850312-34850363 (+)	362 bp
Tssr6239	Chr1:34851832-34851862 (+)	1,871 bp