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Plekhb2 Gene Detail
Summary
  • Symbol
    Plekhb2
  • Name
    pleckstrin homology domain containing, family B (evectins) member 2
  • Synonyms
    2310009M15Rik, evt-2, Phdc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385825
    NCBI Gene: 226971
  • Gene Overview
    MyGene.info: PLEKHB2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:34849976-34879580 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 13.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385825
protein coding gene Chr1:34849941-34879585 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015916
protein coding gene Chr1:33284814-33320481 (+)
A/J MGP_AJ_G0015900
protein coding gene Chr1:32448862-32478927 (+)
AKR/J MGP_AKRJ_G0015855
protein coding gene Chr1:32859226-32890638 (+)
BALB/cJ MGP_BALBcJ_G0015854
protein coding gene Chr1:32122022-32151706 (+)
C3H/HeJ MGP_C3HHeJ_G0015687
protein coding gene Chr1:33069423-33099153 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016307
protein coding gene Chr1:34789370-34821300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014029
protein coding gene Chr1:29584484-29618707 (+)
CAST/EiJ MGP_CASTEiJ_G0015268
protein coding gene Chr1:32954176-32991825 (+)
CBA/J MGP_CBAJ_G0015659
protein coding gene Chr1:35731811-35761236 (+)
DBA/2J MGP_DBA2J_G0015760
protein coding gene Chr1:31803405-31833480 (+)
FVB/NJ MGP_FVBNJ_G0015762
protein coding gene Chr1:31333434-31364028 (+)
LP/J MGP_LPJ_G0015830
protein coding gene Chr1:33637563-33673565 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015782
protein coding gene Chr1:37988582-38018095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016354
protein coding gene Chr1:32870511-32901924 (+)
PWK/PhJ MGP_PWKPhJ_G0015051
protein coding gene Chr1:31533549-31564727 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014833
protein coding gene Chr1:32848623-32889077 (+)
WSB/EiJ MGP_WSBEiJ_G0015330
protein coding gene Chr1:32849109-32880085 (+)



Homology
more
  • Human Ortholog
    PLEKHB2, pleckstrin homology domain containing B2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEKHB2, pleckstrin homology domain containing B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EVT2
  • Links
    NCBI Gene ID: 55041
    neXtProt AC: NX_Q96CS7
    UniProt: Q96CS7

  • Chr Location
    2q21.1; chr2:131104847-131149852 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026123 Ensembl Gene Model | MGI Sequence Detail 29605 C57BL/6J ±  kb
transcript ENSMUST00000027297 Ensembl | MGI Sequence Detail 3279 Not Applicable  
polypeptide ENSMUSP00000027297 Ensembl | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • PDB
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
less
  • All nucleic 185
    cDNA 185

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924835, MGI:2138415
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:78057 Krappa R, et al., Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4633-8
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory