Plekhb2 MGI Mouse Gene Detail - MGI:2385825 - pleckstrin homology domain containing, family B (evectins) member 2

Symbol

Plekhb2
Name

pleckstrin homology domain containing, family B (evectins) member 2
Synonyms

2310009M15Rik, evt-2, Phdc

Feature Type

protein coding gene
IDs

MGI:2385825
NCBI Gene: 226971
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:34889057-34918661 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 13.34 cM
Mapping Data

3 experiments

SNPs within 2kb

1237 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385825	protein coding gene	Chr1:34889040-34918666 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015916	protein coding gene	Chr1:33284814-33320481 (+)
A/J	MGP_AJ_G0015900	protein coding gene	Chr1:32448862-32478927 (+)
AKR/J	MGP_AKRJ_G0015855	protein coding gene	Chr1:32859226-32890638 (+)
BALB/cJ	MGP_BALBcJ_G0015854	protein coding gene	Chr1:32122022-32151706 (+)
C3H/HeJ	MGP_C3HHeJ_G0015687	protein coding gene	Chr1:33069423-33099153 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016307	protein coding gene	Chr1:34789370-34821300 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014029	protein coding gene	Chr1:29584484-29618707 (+)
CAST/EiJ	MGP_CASTEiJ_G0015268	protein coding gene	Chr1:32954176-32991825 (+)
CBA/J	MGP_CBAJ_G0015659	protein coding gene	Chr1:35731811-35761236 (+)
DBA/2J	MGP_DBA2J_G0015760	protein coding gene	Chr1:31803405-31833480 (+)
FVB/NJ	MGP_FVBNJ_G0015762	protein coding gene	Chr1:31333434-31364028 (+)
LP/J	MGP_LPJ_G0015830	protein coding gene	Chr1:33637563-33673565 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015782	protein coding gene	Chr1:37988582-38018095 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016354	protein coding gene	Chr1:32870511-32901924 (+)
PWK/PhJ	MGP_PWKPhJ_G0015051	protein coding gene	Chr1:31533549-31564727 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014833	protein coding gene	Chr1:32848623-32889077 (+)
WSB/EiJ	MGP_WSBEiJ_G0015330	protein coding gene	Chr1:32849109-32880085 (+)

Human Ortholog

PLEKHB2, pleckstrin homology domain containing B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLEKHB2, pleckstrin homology domain containing B2
Synonyms

EVT2
Links

HGNC:19236

NCBI Gene ID: 55041

UniProt: Q96CS7
Chr Location

2q21.1; chr2:131104847-131353709 (+) GRCh38

MGI Vertebrate Homology

Plekhb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLEKHB2
Gene Tree

Plekhb2

less

Phenotype Summary

6 phenotype references

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

19
Genomic Mutations

1 involving Plekhb2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

less

All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

185
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plekhb2

ZFIN plekhb2

less

All Sequences

61
RefSeq

8
UniProt

3
CCDS

CCDS14874.1, CCDS78558.1

Ensembl

ENSMUSG00000026123 (Evidence)
NCBI Gene

226971

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026123	Ensembl Gene Model \| MGI Sequence Detail	29605	C57BL/6J	± kb
transcript	ENSMUST00000027297	Ensembl \| MGI Sequence Detail	3279	Not Applicable
polypeptide	ENSMUSP00000027297	Ensembl \| MGI Sequence Detail	221	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030549 pleckstrin homology domain-containing family B member 2

(term hierarchy)
PDB

2DHI
InterPro Domains

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR039680 Pleckstrin homology domain-containing family B member 1/2
GlyGen

Q9QZC7 1 site

less

All nucleic 186

cDNA 185

Primer pair 1

Microarray probesets 4

less

MGI:1924835, MGI:2138415

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 6
Earliest

J:78057 Krappa R, et al., Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4633-8
Latest

J:283946 Chatterjee S, et al., Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Proc Natl Acad Sci U S A. 2019 Dec 9;

TSS for Plekhb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6235	Chr1:34888775-34888801 (+)	-269 bp
Tssr6236	Chr1:34889018-34889028 (+)	-34 bp
Tssr6237	Chr1:34889031-34889091 (+)	4 bp
Tssr6238	Chr1:34889393-34889444 (+)	362 bp
Tssr6239	Chr1:34890913-34890943 (+)	1,871 bp
Tssr6240	Chr1:34905260-34905281 (+)	16,214 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24