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Mgl2 Gene Detail
Summary
  • Symbol
    Mgl2
  • Name
    macrophage galactose N-acetyl-galactosamine specific lectin 2
  • Synonyms
    CD301b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385729
    NCBI Gene: 216864
  • Gene Overview
    MyGene.info: CLEC10A
Location & Maps
more
  • Sequence Map
    Chr11:70130329-70137550 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7222 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CLEC10A, C-type lectin domain family 10 member A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLEC10A, C-type lectin domain family 10 member A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD301, CLECSF13, CLECSF14, HML, HML2, MGL
  • Links
    NCBI Gene ID: 10462
    neXtProt AC: NX_Q8IUN9

  • Chr Location
    17p13.1; chr17:7074537-7080601 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Mgl2
  • Incidental Mutations
    APF
Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006034 VEGA Gene Model | MGI Sequence Detail 7222 C57BL/6J ±  kb
transcript OTTMUST00000111305 VEGA | MGI Sequence Detail 1635 Not Applicable  
polypeptide OTTMUSP00000062281 VEGA | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    167 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 11
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 15
  • Earliest
    J:78256 Tsuiji M, et al., Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem. 2002 Aug 9;277(32):28892-901
  • Latest
    J:223828 Kashem SW, et al., Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation. Immunity. 2015 Feb 17;42(2):356-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory