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Mgl2
Gene Detail
 Symbol
Name
ID
Mgl2
macrophage galactose N-acetyl-galactosamine specific lectin 2
MGI:2385729
Synonyms CD301b
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70130329-70137550 bp, + strand
From VEGA annotation of GRCm38

  7222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7836  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: asialoglycoprotein receptor 1-like protein
Gene Tree: Mgl2

Human
homologs
Human Homolog CLEC10A, C-type lectin domain family 10, member A
NCBI Gene ID 10462
neXtProt AC  NX_Q8IUN9
Human Synonyms  CD301, CLECSF13, CLECSF14, HML, HML2, MGL
Human Chr (Location)  17p13.1; chr17:7074537-7080307 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from APF )
 
Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity.
 
Interactions
Mgl2 interacts with 57 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (1 annotations)
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (15)    Tissues (14)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
RT-PCR 13
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006034 (Evidence)
Ensembl Gene ModelENSMUSG00000040950 (Evidence)
Entrez Gene216864 (Evidence)
UniGene222465
DFCITC1581920
DoTSDT.94134090
NIA Mouse Gene IndexU092094
Consensus CDS ProjectCCDS24935.1
International Mouse Knockout Project StatusMgl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006034 VEGA Gene Model | MGI Sequence Detail 7222 C57BL/6J ±  kb
transcript OTTMUST00000111305 VEGA | MGI Sequence Detail 1635 Not Applicable 
polypeptide OTTMUSP00000062281 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(3)
Polymorphisms SNPs within 2kb(175 from dbSNP Build 137)    SNPs within 2kb including multiple locations(183)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR005640 Hepatic lectin, N-terminal
References (Earliest) J:78256 Tsuiji M, et al., Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem. 2002 Aug 9;277(32):28892-901
(Latest) J:201044 Kumamoto Y, et al., CD301b Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity. Immunity. 2013 Sep 25;
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory