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Mgl2 Gene Detail
Summary
  • Symbol
    Mgl2
  • Name
    macrophage galactose N-acetyl-galactosamine specific lectin 2
  • Synonyms
    CD301b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385729
    NCBI Gene: 216864
  • Gene Overview
    MyGene.info: CLEC10A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:70130329-70137550 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7222 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CLEC10A, C-type lectin domain containing 10A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLEC10A, C-type lectin domain containing 10A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD301, CLECSF13, CLECSF14, HML, HML2, MGL
  • Links
    NCBI Gene ID: 10462
    neXtProt AC: NX_Q8IUN9
    UniProt: Q8IUN9

  • Chr Location
    17p13.1; chr17:7074537-7080635 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006034 VEGA Gene Model | MGI Sequence Detail 7222 C57BL/6J ±  kb
    transcript OTTMUST00000111305 VEGA | MGI Sequence Detail 1635 Not Applicable  
    polypeptide OTTMUSP00000062281 VEGA | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      167 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR033989 CD209-like, C-type lectin-like domain
      IPR018378 C-type lectin, conserved site
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261189 Kim TG, et al., Skin-Specific CD301b(+) Dermal Dendritic Cells Drive IL-17-Mediated Psoriasis-Like Immune Response in Mice. J Invest Dermatol. 2018 Apr;138(4):844-853

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory