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Mgl2 Gene Detail
Summary
  • Symbol
    Mgl2
  • Name
    macrophage galactose N-acetyl-galactosamine specific lectin 2
  • Synonyms
    CD301b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385729
    NCBI Gene: 216864
  • Gene Overview
    MyGene.info: CLEC10A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70130329-70137550 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385729
protein coding gene Chr11:70130125-70137550 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018582
protein coding gene Chr11:70641587-70649100 (+)
A/J MGP_AJ_G0018550
protein coding gene Chr11:67958758-67963998 (+)
AKR/J MGP_AKRJ_G0018519
protein coding gene Chr11:69982968-69988901 (+)
BALB/cJ MGP_BALBcJ_G0018522
protein coding gene Chr11:68284410-68293098 (+)
C3H/HeJ MGP_C3HHeJ_G0018335
protein coding gene Chr11:70027008-70030972 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018973
protein coding gene Chr11:72750836-72754828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016618
protein coding gene Chr11:64886084-64892533 (+)
CAST/EiJ MGP_CASTEiJ_G0017890
protein coding gene Chr11:70275859-70285144 (+)
CBA/J MGP_CBAJ_G0018307
protein coding gene Chr11:76038910-76042856 (+)
DBA/2J MGP_DBA2J_G0018417
protein coding gene Chr11:67541097-67545892 (+)
FVB/NJ MGP_FVBNJ_G0018407
protein coding gene Chr11:67193106-67197063 (+)
LP/J MGP_LPJ_G0018487
protein coding gene Chr11:71216372-71225292 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018430
protein coding gene Chr11:76607217-76615524 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019015
protein coding gene Chr11:70257764-70266213 (+)
PWK/PhJ MGP_PWKPhJ_G0017664
protein coding gene Chr11:68195700-68203621 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017454
protein coding gene Chr11:70062348-70069570 (+)
WSB/EiJ MGP_WSBEiJ_G0017944
protein coding gene Chr11:69925704-69931063 (+)



Homology
more
  • Human Ortholog
    CLEC10A, C-type lectin domain containing 10A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLEC10A, C-type lectin domain containing 10A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD301, CLECSF13, CLECSF14, HML, HML2, MGL
  • Links
    NCBI Gene ID: 10462
    neXtProt AC: NX_Q8IUN9
    UniProt: Q8IUN9

  • Chr Location
    17p13.1; chr17:7074537-7080635 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040950 Ensembl Gene Model | MGI Sequence Detail 7222 C57BL/6J ±  kb
    transcript ENSMUST00000165951 Ensembl | MGI Sequence Detail 1635 Not Applicable  
    polypeptide ENSMUSP00000131344 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR033989 CD209-like, C-type lectin-like domain
      IPR018378 C-type lectin, conserved site
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 11
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261189 Kim TG, et al., Skin-Specific CD301b(+) Dermal Dendritic Cells Drive IL-17-Mediated Psoriasis-Like Immune Response in Mice. J Invest Dermatol. 2018 Apr;138(4):844-853

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory