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Acsbg1 Gene Detail
Summary
  • Symbol
    Acsbg1
  • Name
    acyl-CoA synthetase bubblegum family member 1
  • Synonyms
    BG1, Bgm, E230019G03Rik, GR-LACS, Lpd, mKIAA0631
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385656
    NCBI Gene: 94180
  • Gene Overview
    MyGene.info: ACSBG1
Location & Maps
more
  • Sequence Map
    Chr9:54604877-54661870 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      56994 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.70 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ACSBG1, acyl-CoA synthetase bubblegum family member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACSBG1, acyl-CoA synthetase bubblegum family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BG, BG1, BGM, GR-LACS, LPD
  • Links
    NCBI Gene ID: 23205
    neXtProt AC: NX_Q96GR2

  • Chr Location
    15q23-q24; chr15:78170845-78234707 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Acsbg1 mouse models

Human Disease Mouse Models
       Adrenoleukodystrophy; ALD   OMIM: 300100
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Targeted
    3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a null mutation display abnormalities in gonadotropin induced changes in testosterone production, Leydig cell morphology and long chain and very long chain fatty acid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    350
  • Tissues
    153
  • cDNA Data
    40
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030280 VEGA Gene Model | MGI Sequence Detail 56994 C57BL/6J ±  kb
transcript OTTMUST00000074956 VEGA | MGI Sequence Detail 2880 Not Applicable  
polypeptide OTTMUSP00000039208 VEGA | MGI Sequence Detail 721 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    524 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003655 long-chain-fatty-acid--CoA ligase ACSBG1
  • EC
    6.2.1.3
  • InterPro Domains
    IPR020845 AMP-binding, conserved site
    IPR000873 AMP-dependent synthetase/ligase
Molecular
Reagents
less
  • All nucleic 42
    cDNA 40
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143449
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:71861 Moriya-Sato A, et al., Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues. Biochem Biophys Res Commun. 2000 Dec 9;279(1):62-8
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory