Acsbg1 MGI Mouse Gene Detail - MGI:2385656 - acyl-CoA synthetase bubblegum family member 1

Acsbg1 Gene Detail

Symbol

Acsbg1
Name

acyl-CoA synthetase bubblegum family member 1
Synonyms

BG1, Bgm, E230019G03Rik, GR-LACS, Lpd, mKIAA0631

Feature Type

protein coding gene
IDs

MGI:2385656
NCBI Gene: 94180
Gene Overview

MyGene.info: ACSBG1

Sequence Map

Chr9:54604877-54661870 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

56994 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.70 cM
Mapping Data

3 experiments

Human Ortholog

ACSBG1, acyl-CoA synthetase bubblegum family member 1

Vertebrate Orthologs

9

Human Ortholog

ACSBG1, acyl-CoA synthetase bubblegum family member 1
Orthology source: HomoloGene, HGNC
Synonyms

BG, BG1, BGM, GR-LACS, LPD
Links

HGNC:29567

NCBI Gene ID: 23205

neXtProt AC: NX_Q96GR2

UniProt: Q96GR2
Chr Location

15q25.1; chr15:78167468-78234707 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9044
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: ACSBG1
Gene Tree

Acsbg1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for a null mutation display abnormalities in gonadotropin induced changes in testosterone production, Leydig cell morphology and long chain and very long chain fatty acid levels.

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All GO Annotations

26
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

350
Tissues

153
cDNA Data

40
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acsbg1

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Acsbg1 interacts with 102 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

39
RefSeq

4
UniProt

4
CCDS

CCDS23192.1
UniGene

20592

			Length	Strain/Species	Flank
genomic	OTTMUSG00000030280	VEGA Gene Model \| MGI Sequence Detail	56994	C57BL/6J	± kb
transcript	OTTMUST00000074956	VEGA \| MGI Sequence Detail	2880	Not Applicable
polypeptide	OTTMUSP00000039208	VEGA \| MGI Sequence Detail	721	Not Applicable

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SNPs within 2kb

524 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000003655 long-chain-fatty-acid--CoA ligase ACSBG1

(term hierarchy)
EC

6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR000873 AMP-dependent synthetase/ligase

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All nucleic 42

cDNA 40

Primer pair 2

Microarray probesets 3

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MGI:2143449

Summaries

All 40

Developmental Gene Expression 7

Diseases 1

Gene Ontology 8

Phenotypes 6
Earliest

J:71861 Moriya-Sato A, et al., Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues. Biochem Biophys Res Commun. 2000 Dec 9;279(1):62-8
Latest

J:235739 Wang S, et al., DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. Development. 2016 Aug 1;143(15):2732-40

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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