Hcrtr1
Gene Detail

Symbol Name ID

Hcrtr1 hypocretin (orexin) receptor 1 MGI:2385650

Synonyms

OX1R

Feature Type

protein coding gene

Genetic Map

Chromosome 4

63.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:130130217-130139359 bp, - strand From VEGA annotation of GRCm38   9143 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Hcrtr1 ± 2 cM)

Protein SuperFamily: orexin receptor
Gene Tree: Hcrtr1

Human ortholog

HCRTR1 hypocretin (orexin) receptor 1 NCBI Gene ID 3061
Human Synonyms: OX1R
Human Chr1:32083301-32092919 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for one null allele display increased susceptibility to pharmacologically induced seizures. Mice homozygous for a second null allele display a decrease in depression like behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	feeding behavior, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, orexin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (85)    Tissues (49)    Images (2)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
In situ reporter (knock in)	35
RT-PCR	50

cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(4) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009509 (Evidence)
Ensembl Gene Model	ENSMUSG00000028778 (Evidence)
Entrez Gene	230777 (Evidence)
UniGene	246595
DFCI	TC1588210
DoTS	DT.110806347, DT.91579532
NIA Mouse Gene Index	U025573
Consensus CDS Project	CCDS18707.1
International Mouse Knockout Project Status	Hcrtr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009509	VEGA Gene Model | MGI Sequence Detail	9143	C57BL/6J
transcript	OTTMUST00000068958	VEGA | MGI Sequence Detail	2161	Not Applicable
polypeptide	OTTMUSP00000034964	VEGA | MGI Sequence Detail	416	Not Applicable

All sequences(35) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000204	Orexin receptor
InterPro	IPR004059	Orexin receptor, type 1
Protein Ontology	PR:000001633	orexin receptor type 1

References

(Earliest) J:46166 Sakurai T, et al., Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [see comments]. Cell. 1998 Feb 20;92(4):573-85
(Latest) J:179764 Duguay D, et al., Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PLoS One. 2011;6(10):e26430
All references(36)