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Lrfn4 Gene Detail
Summary
  • Symbol
    Lrfn4
  • Name
    leucine rich repeat and fibronectin type III domain containing 4
  • Synonyms
    MGC:36464, MGC:36545, SALM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385612
    NCBI Gene: 225875
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4661813-4665695 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385612
 protein coding gene Chr19:4661812-4665962 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024667
 protein coding gene Chr19:1498973-1502855 (-)
A/J MGP_AJ_G0024633
 protein coding gene Chr19:1422025-1425907 (-)
AKR/J MGP_AKRJ_G0024606
 protein coding gene Chr19:1463864-1467746 (-)
BALB/cJ MGP_BALBcJ_G0024633
 protein coding gene Chr19:1417322-1421204 (-)
C3H/HeJ MGP_C3HHeJ_G0024401
 protein coding gene Chr19:1470851-1474733 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025081
 protein coding gene Chr19:1551217-1555099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022510
 protein coding gene Chr19:1357862-1361739 (-)
CAST/EiJ MGP_CASTEiJ_G0023873
 protein coding gene Chr19:1480986-1484869 (-)
CBA/J MGP_CBAJ_G0024372
 protein coding gene Chr19:1618387-1622269 (-)
DBA/2J MGP_DBA2J_G0024500
 protein coding gene Chr19:1386034-1389916 (-)
FVB/NJ MGP_FVBNJ_G0024467
 protein coding gene Chr19:1412187-1416069 (-)
LP/J MGP_LPJ_G0024586
 protein coding gene Chr19:1507619-1511501 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024497
 protein coding gene Chr19:1532357-1536239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025128
 protein coding gene Chr19:1462534-1466416 (-)
PWK/PhJ MGP_PWKPhJ_G0023619
 protein coding gene Chr19:1444339-1448221 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023424
 protein coding gene Chr19:1454707-1458592 (-)
WSB/EiJ MGP_WSBEiJ_G0023935
 protein coding gene Chr19:1458172-1462055 (-)



Homology
more
  • Human Ortholog
    LRFN4, leucine rich repeat and fibronectin type III domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRFN4, leucine rich repeat and fibronectin type III domain containing 4
  • Synonyms
    FIGLER6, SALM3, SALM3.
  • Links
    NCBI Gene ID: 78999
    neXtProt AC: NX_Q6PJG9
    UniProt: Q6PJG9

  • Chr Location
    11q13.2; chr11:66856647-66860475 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display hypoactivity and a decreased excitatory synapse number in the hippocampal CA1 region, but show normal synaptic plasticity and hippocampus-dependent learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    62
  • cDNA Data
    50
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045045 Ensembl Gene Model | MGI Sequence Detail 3883 C57BL/6J ±  kb
transcript ENSMUST00000113822 Ensembl | MGI Sequence Detail 2918 Not Applicable  
polypeptide ENSMUSP00000109453 Ensembl | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 50
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory