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Uroc1
Gene Detail
Symbol

Name
ID
Uroc1
urocanase domain containing 1
MGI:2385332
Synonyms
MGC:37818
Feature Type
protein coding gene
Genetic Map
Chromosome 6
40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:90333289-90364551 bp, + strand
From VEGA annotation of GRCm38

  31263 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UROC1
Protein SuperFamily: urocanate hydratase
Gene Tree: Uroc1

Human
homologs
UROC1, urocanate hydratase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 131669
neXtProt AC: NX_Q96N76

Human Synonyms: HMFN0320, UROCD

Human Chr (Location): 3q21.3; chr3:126481165-126517773 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UROC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Spontaneous(1) Targeted(2)
Genomic Mutations involving Uroc1 (2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Uroc1 interacts with 150 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process histidine catabolic process, histidine metabolic process
Component cytosol
Function lyase activity, urocanate hydratase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (94)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase uroc1    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036118 (Evidence)
Ensembl Gene Model ENSMUSG00000034456 (Evidence)
Entrez Gene 243537 (Evidence)
UniGene 335669
DFCI TC1585213
DoTS DT.91346414, DT.55163562
NIA Mouse Gene Index U007171
EC 4.2.1.49
Consensus CDS Project CCDS39561.1
International Mouse Phenotyping Consortium Status Uroc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036118 VEGA Gene Model | MGI Sequence Detail 31263 C57BL/6J ±  kb
transcript OTTMUST00000092830 VEGA | MGI Sequence Detail 3462 Not Applicable 
polypeptide OTTMUSP00000051375 VEGA | MGI Sequence Detail 710 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(313 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023637 Urocanase
InterPro IPR023636 Urocanase conserved site
Protein Ontology PR:000031440 urocanate hydratase
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)
Other
accession IDs
MGI:2141387

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory