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Lrit1 Gene Detail
Summary
  • Symbol
    Lrit1
  • Name
    leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
  • Synonyms
    Lrrc21, MGC:40670
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385320
    NCBI Gene: 239037
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:37054830-37064946 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 21.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    316 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385320
protein coding gene Chr14:37042475-37064946 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021185
protein coding gene Chr14:30555023-30565914 (+)
A/J MGP_AJ_G0021133
protein coding gene Chr14:29277534-29300630 (+)
AKR/J MGP_AKRJ_G0021110
protein coding gene Chr14:30626769-30638599 (+)
BALB/cJ MGP_BALBcJ_G0021137
protein coding gene Chr14:29521176-29532273 (+)
C3H/HeJ MGP_C3HHeJ_G0020920
protein coding gene Chr14:30510318-30520776 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021569
protein coding gene Chr14:31652706-31662492 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019131
protein coding gene Chr14:29275320-29285081 (+)
CAST/EiJ MGP_CASTEiJ_G0020445
protein coding gene Chr14:30383588-30407488 (+)
CBA/J MGP_CBAJ_G0020886
protein coding gene Chr14:32831217-32843240 (+)
DBA/2J MGP_DBA2J_G0021009
protein coding gene Chr14:29326840-29341735 (+)
FVB/NJ MGP_FVBNJ_G0020993
protein coding gene Chr14:29308954-29318744 (+)
LP/J MGP_LPJ_G0021078
protein coding gene Chr14:30849784-30859547 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021019
protein coding gene Chr14:32023321-32046245 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021602
protein coding gene Chr14:30488552-30500524 (+)
PWK/PhJ MGP_PWKPhJ_G0020193
protein coding gene Chr14:28860608-28884612 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020017
protein coding gene Chr14:30025130-30047873 (+)
WSB/EiJ MGP_WSBEiJ_G0020500
protein coding gene Chr14:30517046-30526833 (+)



Homology
more
  • Human Ortholog
    LRIT1, leucine rich repeat, Ig-like and transmembrane domains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRIT1, leucine rich repeat, Ig-like and transmembrane domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIGLER9, LRRC21, PAL
  • Links
    NCBI Gene ID: 26103
    neXtProt AC: NX_Q9P2V4
    UniProt: Q9P2V4

  • Chr Location
    10q23.1; chr10:84231520-84241461 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9215
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRIT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired synaptic communication of cone photoreceptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041044 Ensembl Gene Model | MGI Sequence Detail 10117 C57BL/6J ±  kb
transcript ENSMUST00000120052 Ensembl | MGI Sequence Detail 4325 Not Applicable  
polypeptide ENSMUSP00000113964 Ensembl | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:271244 Ueno A, et al., Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Cell Rep. 2018 Mar 27;22(13):3548-3561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory