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Dlat Gene Detail
Summary
  • Symbol
    Dlat
  • Name
    dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
  • Synonyms
    6332404G05Rik, PDC-E2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385311
    NCBI Gene: 235339
  • Gene Overview
    MyGene.info: DLAT
Location & Maps
more
  • Sequence Map
    Chr9:50634633-50659780 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25148 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLAT, dihydrolipoamide S-acetyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLAT, dihydrolipoamide S-acetyltransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DLTA, PDCE2, PDC-E2
  • Links
    NCBI Gene ID: 1737
    neXtProt AC: NX_P10515

  • Chr Location
    11q23.1; chr11:112024814-112064278 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DLAT associations

Human Disease Mouse Models
       Pyruvate Dehydrogenase E2 Deficiency; PDHDD   OMIM: 245348
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016493 VEGA Gene Model | MGI Sequence Detail 25148 C57BL/6J ±  kb
transcript OTTMUST00000039807 VEGA | MGI Sequence Detail 4035 Not Applicable  
polypeptide OTTMUSP00000017759 VEGA | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    268 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006504 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
  • EC
  • InterPro Domains
    IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
    IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
    IPR000089 Biotin/lipoyl attachment
    IPR023213 Chloramphenicol acetyltransferase-like domain
    IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    IPR004167 E3-binding domain
    IPR011053 Single hybrid motif
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2444090
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 3
  • Earliest
    J:79566 Wang L, et al., Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. J Gastroenterol. 2002;37(6):449-54
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory