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Dlat Gene Detail
Summary
  • Symbol
    Dlat
  • Name
    dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
  • Synonyms
    6332404G05Rik, PDC-E2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385311
    NCBI Gene: 235339
  • Gene Overview
    MyGene.info: DLAT
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50634633-50659780 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385311
protein coding gene Chr9:50634633-50659780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034785
protein coding gene Chr9:49529605-49558188 (-)
A/J MGP_AJ_G0034766
protein coding gene Chr9:48018812-48044762 (-)
AKR/J MGP_AKRJ_G0034694
protein coding gene Chr9:49028699-49053839 (-)
BALB/cJ MGP_BALBcJ_G0034758
protein coding gene Chr9:47743587-47768993 (-)
C3H/HeJ MGP_C3HHeJ_G0034468
protein coding gene Chr9:49510832-49538201 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035278
protein coding gene Chr9:50911577-50940169 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032191
protein coding gene Chr9:47482734-47508338 (-)
CAST/EiJ MGP_CASTEiJ_G0033790
protein coding gene Chr9:49463486-49490874 (-)
CBA/J MGP_CBAJ_G0034440
protein coding gene Chr9:52721108-52749153 (-)
DBA/2J MGP_DBA2J_G0034599
protein coding gene Chr9:47878711-47903862 (-)
FVB/NJ MGP_FVBNJ_G0034540
protein coding gene Chr9:47096058-47121068 (-)
LP/J MGP_LPJ_G0034680
protein coding gene Chr9:49888859-49915245 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034583
protein coding gene Chr9:54319157-54344383 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035299
protein coding gene Chr9:49001626-49027653 (-)
PWK/PhJ MGP_PWKPhJ_G0033495
protein coding gene Chr9:47855619-47881079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033330
protein coding gene Chr9:49313236-49339837 (-)
WSB/EiJ MGP_WSBEiJ_G0033903
protein coding gene Chr9:49010712-49038673 (-)



Homology
more
  • Human Ortholog
    DLAT, dihydrolipoamide S-acetyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLAT, dihydrolipoamide S-acetyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DLTA, PDCE2, PDC-E2
  • Links
    NCBI Gene ID: 1737
    neXtProt AC: NX_P10515
    UniProt: P10515

  • Chr Location
    11q23.1; chr11:112024814-112064278 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DLAT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 235339 NCBI Gene Model | MGI Sequence Detail 25148 C57BL/6J ±  kb
transcript NM_145614 RefSeq | MGI Sequence Detail 4051 C57BL/6  
polypeptide Q8BMF4 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006504 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
  • EC
  • InterPro Domains
    IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
    IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
    IPR000089 Biotin/lipoyl attachment
    IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
    IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    IPR036625 E3-binding domain superfamily
    IPR004167 Peripheral subunit-binding domain
    IPR011053 Single hybrid motif
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2444090
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 4
  • Earliest
    J:79566 Wang L, et al., Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. J Gastroenterol. 2002;37(6):449-54
  • Latest
    J:253139 Richard AJ, et al., Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue. J Biol Chem. 2017 Dec 1;292(48):19733-19742

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory