Dlat
Gene Detail

Symbol Name ID

Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) MGI:2385311

Synonyms

6332404G05Rik, PDC-E2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:50634633-50659780 bp, - strand From VEGA annotation of GRCm38   25148 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pyruvate dehydrogenase complex, dihydrolipoyllysine-residue acetyltransferase component
Gene Tree: Dlat

Human homologs

Human Homolog		DLAT, dihydrolipoamide S-acetyltransferase
NCBI Gene ID		1737
neXtProt AC		NX_P10515
Human Synonyms		DLTA, PDCE2, PDC-E2
Human Chr (Location)		11q23.1; chr11:111895538-111935002 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DLAT

Alleles and phenotypes

All alleles(3) : Targeted(1) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component	mitochondrial pyruvate dehydrogenase complex, mitochondrion, ...
Function	dihydrolipoyllysine-residue acetyltransferase activity, transferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (212)    Tissues (109)    Images (10)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	212

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016493 (Evidence)
Ensembl Gene Model	ENSMUSG00000000168 (Evidence)
Entrez Gene	235339 (Evidence)
DFCI	TC1572889
DoTS	DT.101363265, DT.534273, DT.99860170
NIA Mouse Gene Index	U030844
EC	2.3.1.12
Consensus CDS Project	CCDS23168.1
International Mouse Knockout Project Status	Dlat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016493	VEGA Gene Model | MGI Sequence Detail	25148	C57BL/6J
transcript	OTTMUST00000039807	VEGA | MGI Sequence Detail	4035	Not Applicable
polypeptide	OTTMUSP00000017759	VEGA | MGI Sequence Detail	642	Not Applicable

All sequences(49) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(158 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001078	2-oxoacid dehydrogenase acyltransferase, catalytic domain
InterPro	IPR003016	2-oxo acid dehydrogenase, lipoyl-binding site
InterPro	IPR000089	Biotin/lipoyl attachment
InterPro	IPR023213	Chloramphenicol acetyltransferase-like domain
InterPro	IPR006257	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
InterPro	IPR004167	E3 binding
InterPro	IPR011053	Single hybrid motif
Protein Ontology	PR:000006504	dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

References

(Earliest) J:79566 Wang L, et al., Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. J Gastroenterol. 2002;37(6):449-54
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Other accession IDs

MGI:2444090