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Dlat
Gene Detail
 Symbol
Name
ID
Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
MGI:2385311
Synonyms 6332404G05Rik, PDC-E2
Feature Type protein coding gene
Genetic Map
Chromosome 9
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:50634633-50659780 bp, - strand
From VEGA annotation of GRCm38

  25148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: pyruvate dehydrogenase complex, dihydrolipoyllysine-residue acetyltransferase component
Gene Tree: Dlat

Human
homologs
Human Homolog DLAT, dihydrolipoamide S-acetyltransferase
NCBI Gene ID 1737
neXtProt AC  NX_P10515
Human Synonyms  DLTA, PDCE2, PDC-E2
Human Chr (Location)  11q23.1; chr11:112024814-112064278 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DLAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dlat interacts with 261 markers (Mir1b, Mir7-1, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component mitochondrial pyruvate dehydrogenase complex, mitochondrion, ...
Function dihydrolipoyllysine-residue acetyltransferase activity, transferase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (212)    Tissues (109)    Images (10)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 212
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016493 (Evidence)
Ensembl Gene ModelENSMUSG00000000168 (Evidence)
Entrez Gene235339 (Evidence)
DFCITC1572889
DoTSDT.101363265, DT.534273, DT.99860170
NIA Mouse Gene IndexU030844
EC2.3.1.12
Consensus CDS ProjectCCDS23168.1
International Mouse Knockout Project StatusDlat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016493 VEGA Gene Model | MGI Sequence Detail 25148 C57BL/6J ±  kb
transcript OTTMUST00000039807 VEGA | MGI Sequence Detail 4035 Not Applicable 
polypeptide OTTMUSP00000017759 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
InterPro IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR023213 Chloramphenicol acetyltransferase-like domain
InterPro IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
InterPro IPR004167 E3 binding
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000006504 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
References (Earliest) J:79566 Wang L, et al., Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells. J Gastroenterol. 2002;37(6):449-54
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2444090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory