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Map3k21 Gene Detail
Summary
  • Symbol
    Map3k21
  • Name
    mitogen-activated protein kinase kinase kinase 21
  • Synonyms
    BC021891, MGC:27778
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385307
    NCBI Gene: 234878
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125910450-125947440 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 73.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385307
protein coding gene Chr8:125910450-125947440 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034290
protein coding gene Chr8:129705705-129742688 (+)
A/J MGP_AJ_G0034270
protein coding gene Chr8:124323607-124360571 (+)
AKR/J MGP_AKRJ_G0034197
protein coding gene Chr8:127888418-127925707 (+)
BALB/cJ MGP_BALBcJ_G0034263
protein coding gene Chr8:124486560-124523539 (+)
C3H/HeJ MGP_C3HHeJ_G0033974
protein coding gene Chr8:128542513-128580746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034783
protein coding gene Chr8:134014584-134051494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031724
protein coding gene Chr8:117052719-117092487 (+)
CAST/EiJ MGP_CASTEiJ_G0033301
protein coding gene Chr8:128694899-128731759 (+)
CBA/J MGP_CBAJ_G0033947
protein coding gene Chr8:138950276-138989437 (+)
DBA/2J MGP_DBA2J_G0034103
protein coding gene Chr8:123465548-123502531 (+)
FVB/NJ MGP_FVBNJ_G0034047
protein coding gene Chr8:122663193-122700905 (+)
LP/J MGP_LPJ_G0034192
protein coding gene Chr8:129852104-129889071 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034094
protein coding gene Chr8:140942834-140980039 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034802
protein coding gene Chr8:128130987-128169965 (+)
PWK/PhJ MGP_PWKPhJ_G0033003
protein coding gene Chr8:123230358-123266988 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032842
protein coding gene Chr8:126760303-126799118 (+)
WSB/EiJ MGP_WSBEiJ_G0033418
protein coding gene Chr8:128863620-128900634 (+)



Homology
more
  • Human Ortholog
    MAP3K21, mitogen-activated protein kinase kinase kinase 21
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAP3K21, mitogen-activated protein kinase kinase kinase 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ862P8.3, MLK4
  • Links
    NCBI Gene ID: 84451
    neXtProt AC: NX_Q5TCX8
    UniProt: Q5TCX8

  • Chr Location
    1q42.2; chr1:233327732-233385148 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 234878 NCBI Gene Model | MGI Sequence Detail 36991 C57BL/6J ±  kb
transcript NM_145608 RefSeq | MGI Sequence Detail 5692 Not Specified  
polypeptide Q8VDG6 UniProt | EBI | MGI Sequence Detail 1002 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory