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Suv420h2
Gene Detail
 Symbol
Name
ID
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
MGI:2385262
Synonyms KMT5C, MGC:36471, Suv4-20h2
Feature Type protein coding gene
Genetic Map
Chromosome 7
2.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:4740115-4747514 bp, + strand
From VEGA annotation of GRCm38

  7400 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Suv420h2

Human
homologs
Human Homolog SUV420H2, suppressor of variegation 4-20 homolog 2 (Drosophila)
NCBI Gene ID 84787
neXtProt AC  NX_Q86Y97
Human Synonyms  KMT5C
Human Chr (Location)  19q13.42; chr19:55339853-55348121 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit no apparent defects and develop normally.
 
Interactions
Suv420h2 interacts with 127 markers (Mir24-1, Mir24-2, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chromatin modification, histone H4-K20 methylation, ...
Component chromosome, condensed nuclear chromosome, centromeric region, ...
Function histone-lysine N-methyltransferase activity, histone methyltransferase activity (H4-K20 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (114)    Tissues (109)    Images (14)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 100
Northern blot 14
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017303 (Evidence)
Ensembl Gene ModelENSMUSG00000059851 (Evidence)
Entrez Gene232811 (Evidence)
UniGene247844
DFCITC1576488, TC1700983
DoTSDT.101734805, DT.103546989, DT.531777, DT.94395018
NIA Mouse Gene IndexU119121
EC2.1.1.43
PDB4AU7
Consensus CDS ProjectCCDS20743.2
International Mouse Knockout Project StatusSuv420h2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017303 VEGA Gene Model | MGI Sequence Detail 7400 C57BL/6J ±  kb
transcript OTTMUST00000041979 VEGA | MGI Sequence Detail 2189 Not Applicable 
polypeptide OTTMUSP00000018878 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025790 Histone-lysine N-methyltransferase, Suvar4-20
InterPro IPR001214 SET domain
Protein Ontology PR:000015847 histone-lysine N-methyltransferase SUV420H2
References (Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory