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Suv420h2
Gene Detail
Symbol

Name
ID
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
MGI:2385262
Synonyms
KMT5C, MGC:36471, Suv4-20h2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:4740115-4747514 bp, + strand
From VEGA annotation of GRCm38

  7400 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SUV420H2
Gene Tree: Suv420h2

Human
homologs
SUV420H2, suppressor of variegation 4-20 homolog 2 (Drosophila)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84787
neXtProt AC: NX_Q86Y97

Human Synonyms: KMT5C

Human Chr (Location): 19q13.42; chr19:55339210-55348121 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit no apparent defects and develop normally.
 
Interactions
Suv420h2 interacts with 127 markers (Mir24-1, Mir24-2, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (114)    Tissues (109)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
Northern blot 14
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100145748    NEW 
Molecular
reagents
All nucleic(78) cDNA(78)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017303 (Evidence)
Ensembl Gene Model ENSMUSG00000059851 (Evidence)
Entrez Gene 232811 (Evidence)
UniGene 247844
DFCI TC1700983, TC1576488
DoTS DT.94395018, DT.531777, DT.103546989, DT.101734805
NIA Mouse Gene Index U119121
EC 2.1.1.43
PDB 4AU7
Consensus CDS Project CCDS20743.2
International Mouse Phenotyping Consortium Status Suv420h2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017303 VEGA Gene Model | MGI Sequence Detail 7400 C57BL/6J ±  kb
transcript OTTMUST00000041979 VEGA | MGI Sequence Detail 2189 Not Applicable 
polypeptide OTTMUSP00000018878 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(18) UniProt(4)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025790 Histone-lysine N-methyltransferase, Suvar4-20
InterPro IPR001214 SET domain
Protein Ontology PR:000015847 histone-lysine N-methyltransferase SUV420H2
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory