Suv420h2
Gene Detail

Symbol Name ID

Suv420h2 suppressor of variegation 4-20 homolog 2 (Drosophila) MGI:2385262

Synonyms

KMT5C, MGC:36471, Suv4-20h2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

2.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:4740115-4747514 bp, + strand From VEGA annotation of GRCm38   7400 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Suv420h2

Human homologs

Human Homolog		SUV420H2, suppressor of variegation 4-20 homolog 2 (Drosophila)
NCBI Gene ID		84787
neXtProt AC		NX_Q86Y97
Human Synonyms		KMT5C
Human Chr (Location)		19q13.42; chr19:55851221-55859489 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(4) Gene trapped(14)
 

Mice homozygous for a knock-out allele exhibit no apparent defects and develop normally.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	chromatin modification, histone H4-K20 methylation, ...
Component	chromosome, condensed nuclear chromosome, centromeric region, ...
Function	histone-lysine N-methyltransferase activity, histone methyltransferase activity (H4-K20 specific), ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (114)    Tissues (109)    Images (14)
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	100
Northern blot	14

cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(77) cDNA(77)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017303 (Evidence)
Ensembl Gene Model	ENSMUSG00000059851 (Evidence)
Entrez Gene	232811 (Evidence)
UniGene	247844
DFCI	TC1576488, TC1700983
DoTS	DT.101734805, DT.103546989, DT.531777, DT.94395018
NIA Mouse Gene Index	U119121
EC	2.1.1.43
Consensus CDS Project	CCDS20743.2
International Mouse Knockout Project Status	Suv420h2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017303	VEGA Gene Model | MGI Sequence Detail	7400	C57BL/6J
transcript	OTTMUST00000041979	VEGA | MGI Sequence Detail	2189	Not Applicable
polypeptide	OTTMUSP00000018878	VEGA | MGI Sequence Detail	468	Not Applicable

All sequences(67) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025790	Histone-lysine N-methyltransferase, Suvar4-20
InterPro	IPR001214	SET domain
Protein Ontology	PR:000015847	histone-lysine N-methyltransferase SUV420H2

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
All references(38)