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Tmprss11d
Gene Detail
Symbol

Name
ID
Tmprss11d
transmembrane protease, serine 11d
MGI:2385221
Synonyms
AsP, MGC:28382
Feature Type
protein coding gene
Genetic Map
Chromosome 5
43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:86302217-86373420 bp, - strand
From VEGA annotation of GRCm38

  71204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: transmembrane serine protease, TMPRSS11A type
Gene Tree: Tmprss11d

Human
homologs
Human Homolog TMPRSS11D, transmembrane protease, serine 11D
NCBI Gene ID 9407
neXtProt AC  NX_O60235
Human Synonyms  HAT
Human Chr (Location)  4q13.2; chr4:67820876-67883998 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Aged female mice homozygous for a knock-in allele exhibit increased lymphoma incidence.
 
Interactions
Tmprss11d interacts with 182 markers (Mir7-1, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process proteolysis, regulation of growth
Component cell surface, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (11)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
RT-PCR 7
cDNA source data(1)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(1) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028240 (Evidence)
Ensembl Gene ModelENSMUSG00000061259 (Evidence)
Entrez Gene231382 (Evidence)
UniGene240139
DFCITC1589260
DoTSDT.101712268, DT.91351174
NIA Mouse Gene IndexU026347
EC3.4.21.-
PDB2E7V
Consensus CDS ProjectCCDS39124.1
International Mouse Knockout Project StatusTmprss11d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028240 VEGA Gene Model | MGI Sequence Detail 71204 C57BL/6J ±  kb
transcript OTTMUST00000069973 VEGA | MGI Sequence Detail 2716 Not Applicable 
polypeptide OTTMUSP00000035603 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(474 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR017329 Peptidase S1A, HAT/DESC1
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000082 SEA domain
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016450 transmembrane protease serine 11D
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:207757 Heurich A, et al., TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol. 2014 Jan;88(2):1293-307
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory