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Pabpc4 Gene Detail
Summary
  • Symbol
    Pabpc4
  • Name
    poly(A) binding protein, cytoplasmic 4
  • Synonyms
    MGC:11665, MGC:6685
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385206
    NCBI Gene: 230721
  • Gene Overview
    MyGene.info: PABPC4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123282716-123298832 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385206
protein coding gene Chr4:123262351-123298925 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028739
protein coding gene Chr4:124691619-124743995 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0028651
protein coding gene Chr4:123063518-123102323 (+)
BALB/cJ MGP_BALBcJ_G0028720
protein coding gene Chr4:120407757-120444049 (+)
C3H/HeJ MGP_C3HHeJ_G0028436
protein coding gene Chr4:123171705-123213554 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029162
protein coding gene Chr4:129506258-129549744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026435
protein coding gene Chr4:113046400-113081925 (+)
CAST/EiJ MGP_CASTEiJ_G0027867
protein coding gene Chr4:121197511-121233130 (+)
CBA/J MGP_CBAJ_G0028401
protein coding gene Chr4:132788860-132835730 (+)
DBA/2J MGP_DBA2J_G0028550
protein coding gene Chr4:120328159-120365614 (+)
FVB/NJ MGP_FVBNJ_G0028517
protein coding gene Chr4:118947346-118986979 (+)
LP/J MGP_LPJ_G0028651
protein coding gene Chr4:124967493-125015152 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028543
protein coding gene Chr4:137734581-137784638 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029200
protein coding gene Chr4:123439837-123486604 (+)
PWK/PhJ MGP_PWKPhJ_G0027589
protein coding gene Chr4:116722832-116759664 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027415
protein coding gene Chr4:119256223-119293442 (+)
WSB/EiJ MGP_WSBEiJ_G0027947
protein coding gene Chr4:123514447-123553899 (+)



Homology
more
  • Human Ortholog
    PABPC4, poly(A) binding protein cytoplasmic 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PABPC4, poly(A) binding protein cytoplasmic 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APP1, APP-1, iPABP, PABP4
  • Links
    NCBI Gene ID: 8761
    neXtProt AC: NX_Q13310
    UniProt: Q13310

  • Chr Location
    1p34.3; chr1:39560813-39576849 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230721 NCBI Gene Model | MGI Sequence Detail 16117 C57BL/6J ±  kb
    transcript NM_130881 RefSeq | MGI Sequence Detail 3112 C57BL/6  
    polypeptide NP_570951 RefSeq | MGI Sequence Detail 660 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR036053 PABC (PABP) domain
      IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
      IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR003954 RNA recognition motif domain, eukaryote
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 12
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:225710 Tuck E, et al., A gene expression resource generated by genome-wide lacZ profiling in the mouse. Dis Model Mech. 2015 Nov 1;8(11):1467-78

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory