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Pabpc4
Gene Detail
Symbol

Name
ID
Pabpc4
poly(A) binding protein, cytoplasmic 4
MGI:2385206
Synonyms
MGC:11665, MGC:6685
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:123262351-123298925 bp, + strand
From VEGA annotation of GRCm38

  36575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PABPC4
Gene Tree: Pabpc4

Human
homologs
PABPC4, poly(A) binding protein, cytoplasmic 4 (inducible form)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8761
neXtProt AC: NX_Q13310

Human Synonyms: APP1, APP-1, iPABP, PABP4

Human Chr (Location): 1p34.2; chr1:39560813-39576849 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Genomic Mutations involving Pabpc4 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pabpc4 interacts with 70 markers (Mir1b, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process myeloid cell development, regulation of mRNA stability
Component cytoplasm, cytoplasmic stress granule, ...
Function mRNA binding, poly(A) binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (23)    Tissues (23)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 2
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pabpc4    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000008978 (Evidence)
Ensembl Gene Model ENSMUSG00000011257 (Evidence)
Entrez Gene 230721 (Evidence)
DFCI TC1572831, TC1649567
Consensus CDS Project CCDS18614.1, CCDS18615.1
International Mouse Phenotyping Consortium Status Pabpc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008978 VEGA Gene Model | MGI Sequence Detail 36575 C57BL/6J ±  kb
transcript OTTMUST00000020376 VEGA | MGI Sequence Detail 3019 Not Applicable 
polypeptide OTTMUSP00000009342 VEGA | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
InterPro IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
InterPro IPR000504 RNA recognition motif domain
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:213525 Kini HK, et al., Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Mol Cell Biol. 2014 Apr;34(7):1300-9
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory