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Tesk2
Gene Detail
Symbol

Name
ID
Tesk2
testis-specific kinase 2
MGI:2385204
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:116720948-116805956 bp, + strand
From VEGA annotation of GRCm38

  85009 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TESK2
Protein SuperFamily: dual specificity testis-specific protein kinase
Gene Tree: Tesk2

Human
homologs
TESK2, testis-specific kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10420
neXtProt AC: NX_Q96S53

Human Chr (Location): 1p32; chr1:45343883-45491342 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(71) Targeted(3)
Genomic Mutations involving Tesk2 (1)
Incidental mutations (data from APF )
Interactions
Tesk2 interacts with 212 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin cytoskeleton organization, focal adhesion assembly, ...
Component cytoplasm, nucleoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (114)    Tissues (98)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 114
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tesk2    NEW 
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000009675 (Evidence)
Ensembl Gene Model ENSMUSG00000033985 (Evidence)
Entrez Gene 230661 (Evidence)
UniGene 482431
DFCI TC1594377, TC1581610
EC 2.7.12.1
Consensus CDS Project CCDS18516.1
International Mouse Phenotyping Consortium Status Tesk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009675 VEGA Gene Model | MGI Sequence Detail 85009 C57BL/6J ±  kb
transcript OTTMUST00000022336 VEGA | MGI Sequence Detail 3033 Not Applicable 
polypeptide OTTMUSP00000010191 VEGA | MGI Sequence Detail 570 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
Protein Ontology PR:000016242 dual specificity testis-specific protein kinase 2
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory