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Usp1
Gene Detail
Symbol

Name
ID
Usp1
ubiquitin specific peptidase 1
MGI:2385198
Feature Type
protein coding gene
Genetic Map
Chromosome 4
45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:98923810-98935543 bp, + strand
From VEGA annotation of GRCm38

  11734 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Usp1

Human
homologs
Human Homolog USP1, ubiquitin specific peptidase 1
NCBI Gene ID 7398
neXtProt AC  NX_O94782
Human Synonyms  UBP
Human Chr (Location)  1p31.3; chr1:62436304-62451804 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(19) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous null mice have a high rate of postnatal lethality related to cyanosis. Male survivors are infertile while female survivors have reduced fertility. Both sexes have reduced number of gametes, are sensitive to ionizing radiation, and have decreased numbers of bone marrow cells.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Usp1 interacts with 227 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component nucleus
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (4)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(125)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(126) cDNA(126)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008702 (Evidence)
Ensembl Gene ModelENSMUSG00000028560 (Evidence)
Entrez Gene230484 (Evidence)
UniGene371692
DFCITC1572816
DoTSDT.533049, DT.99858403
NIA Mouse Gene IndexU004526, U071824
EC3.4.19.12
Consensus CDS ProjectCCDS18381.1
International Mouse Knockout Project StatusUsp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008702 VEGA Gene Model | MGI Sequence Detail 11734 C57BL/6J ±  kb
transcript OTTMUST00000019756 VEGA | MGI Sequence Detail 3527 Not Applicable 
polypeptide OTTMUSP00000009051 VEGA | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017145 ubiquitin carboxyl-terminal hydrolase 1
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:199241 Park E, et al., FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis. Mol Cell. 2013 Jun 27;50(6):908-18
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory