Usp1
Gene Detail

Symbol Name ID

Usp1 ubiquitin specific peptidase 1 MGI:2385198

Feature Type

protein coding gene

Genetic Map

Chromosome 4

45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:98923810-98935543 bp, + strand From VEGA annotation of GRCm38   11734 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Usp1

Human homologs

Human Homolog		USP1, ubiquitin specific peptidase 1
NCBI Gene ID		7398
neXtProt AC		NX_O94782
Human Synonyms		UBP
Human Chr (Location)		1p31.3; chr1:62901975-62917475 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(22) : Targeted(3) Gene trapped(19)
 

Homozygous null mice have a high rate of postnatal lethality related to cyanosis. Male survivors are infertile while female survivors have reduced fertility. Both sexes have reduced number of gametes, are sensitive to ionizing radiation, and have decreased numbers of bone marrow cells.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	DNA repair, monoubiquitinated protein deubiquitination, ...
Component	nucleus
Function	cysteine-type peptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (3)    Images (9)
Theiler Stages: 28

Assay Type	Results
RNA in situ	7

cDNA source data(118)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(119) cDNA(119)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008702 (Evidence)
Ensembl Gene Model	ENSMUSG00000028560 (Evidence)
Entrez Gene	230484 (Evidence)
UniGene	371692
DFCI	TC1572816
DoTS	DT.533049, DT.99858403
NIA Mouse Gene Index	U004526, U071824
EC	3.4.19.12
Consensus CDS Project	CCDS18381.1
International Mouse Knockout Project Status	Usp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008702	VEGA Gene Model | MGI Sequence Detail	11734	C57BL/6J
transcript	OTTMUST00000019757	VEGA | MGI Sequence Detail	3577	Not Applicable
polypeptide	OTTMUSP00000009052	VEGA | MGI Sequence Detail	784	Not Applicable

All sequences(38) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro	IPR018200	Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology	PR:000017145	ubiquitin carboxyl-terminal hydrolase 1

References

(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)