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Usp1
Gene Detail
 Symbol
Name
ID
Usp1
ubiquitin specific peptidase 1
MGI:2385198
Feature Type protein coding gene
Genetic Map
Chromosome 4
45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:98923810-98935543 bp, + strand
From VEGA annotation of GRCm38

  11734 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Usp1

Human
homologs
Human Homolog USP1, ubiquitin specific peptidase 1
NCBI Gene ID 7398
neXtProt AC  NX_O94782
Human Synonyms  UBP
Human Chr (Location)  1p31.3; chr1:62436304-62451804 (+)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Targeted(3) Gene trapped(19)
 
Homozygous null mice have a high rate of postnatal lethality related to cyanosis. Male survivors are infertile while female survivors have reduced fertility. Both sexes have reduced number of gametes, are sensitive to ionizing radiation, and have decreased numbers of bone marrow cells.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component nucleus
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (3)    Images (9)
Theiler Stages: 28
Assay TypeResults
RNA in situ 7
cDNA source data(125)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(126) cDNA(126)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008702 (Evidence)
Ensembl Gene ModelENSMUSG00000028560 (Evidence)
Entrez Gene230484 (Evidence)
UniGene371692
DFCITC1572816
DoTSDT.533049, DT.99858403
NIA Mouse Gene IndexU004526, U071824
EC3.4.19.12
Consensus CDS ProjectCCDS18381.1
International Mouse Knockout Project StatusUsp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008702 VEGA Gene Model | MGI Sequence Detail 11734 C57BL/6J ±  kb
transcript OTTMUST00000019757 VEGA | MGI Sequence Detail 3577 Not Applicable 
polypeptide OTTMUSP00000009052 VEGA | MGI Sequence Detail 784 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000017145 ubiquitin carboxyl-terminal hydrolase 1
References (Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:206104 Adelman CA, et al., HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature. 2013 Oct 17;502(7471):381-4
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory