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Usp1 Gene Detail
Summary
  • Symbol
    Usp1
  • Name
    ubiquitin specific peptidase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385198
    NCBI Gene: 230484
  • Gene Overview
    MyGene.info: USP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:98923810-98935543 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 45.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385198
protein coding gene Chr4:98923623-98935543 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028476
protein coding gene Chr4:99113833-99134420 (+)
A/J MGP_AJ_G0028439
protein coding gene Chr4:95682365-95694454 (+)
AKR/J MGP_AKRJ_G0028386
protein coding gene Chr4:97997496-98012831 (+)
BALB/cJ MGP_BALBcJ_G0028457
protein coding gene Chr4:95924464-95936370 (+)
C3H/HeJ MGP_C3HHeJ_G0028170
protein coding gene Chr4:98794398-98805868 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028896
protein coding gene Chr4:102886672-102903246 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026188
protein coding gene Chr4:91063309-91075228 (+)
CAST/EiJ MGP_CASTEiJ_G0027610
protein coding gene Chr4:96580596-96598275 (+)
CBA/J MGP_CBAJ_G0028139
protein coding gene Chr4:106041356-106055460 (+)
DBA/2J MGP_DBA2J_G0028289
protein coding gene Chr4:95417048-95430414 (+)
FVB/NJ MGP_FVBNJ_G0028256
protein coding gene Chr4:94258806-94270409 (+)
LP/J MGP_LPJ_G0028389
protein coding gene Chr4:99443663-99456303 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028284
protein coding gene Chr4:111778199-111790677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028934
protein coding gene Chr4:98242602-98259451 (+)
PWK/PhJ MGP_PWKPhJ_G0027335
protein coding gene Chr4:93557824-93570256 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027156
protein coding gene Chr4:95682050-95698304 (+)
WSB/EiJ MGP_WSBEiJ_G0027688
protein coding gene Chr4:98377527-98391752 (+)



Homology
more
  • Human Ortholog
    USP1, ubiquitin specific peptidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP1, ubiquitin specific peptidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    UBP
  • Links
    NCBI Gene ID: 7398
    neXtProt AC: NX_O94782
    UniProt: O94782

  • Chr Location
    1p31.3; chr1:62436304-62451804 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2528
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Usp1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have a high rate of postnatal lethality related to cyanosis. Male survivors are infertile while female survivors have reduced fertility. Both sexes have reduced number of gametes, are sensitive to ionizing radiation, and have decreased numbers of bone marrow cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028560 Ensembl Gene Model | MGI Sequence Detail 11734 C57BL/6J ±  kb
    transcript ENSMUST00000091358 Ensembl | MGI Sequence Detail 3527 Not Applicable  
    polypeptide ENSMUSP00000088917 Ensembl | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 127

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:229978 Kim M, et al., The role of USP1 autocleavage in DNA interstrand crosslink repair. FEBS Lett. 2016 Feb;590(3):340-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory