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Gtf2b Gene Detail
Summary
  • Symbol
    Gtf2b
  • Name
    general transcription factor IIB
  • Synonyms
    MGC:6859
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385191
    NCBI Gene: 229906
  • Gene Overview
    MyGene.info: GTF2B
Location & Maps
more
  • Sequence Map
    Chr3:142765045-142783606 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18562 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GTF2B, general transcription factor IIB
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTF2B, general transcription factor IIB
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TF2B, TFIIB
  • Links
    NCBI Gene ID: 2959
    neXtProt AC: NX_Q00403

  • Chr Location
    1p22-p21; chr1:88852638-88891944 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Gtf2b
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054080 VEGA Gene Model | MGI Sequence Detail 18562 C57BL/6J ±  kb
transcript OTTMUST00000134388 VEGA | MGI Sequence Detail 1455 Not Applicable  
polypeptide OTTMUSP00000071270 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    157 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008313 transcription initiation factor IIB
  • InterPro Domains
    IPR013763 Cyclin-like
    IPR000812 Transcription factor TFIIB
    IPR023486 Transcription factor TFIIB, conserved site
    IPR013150 Transcription factor TFIIB, cyclin-like domain
    IPR013137 Zinc finger, TFIIB-type
Molecular
Reagents
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  • All nucleic 75
    cDNA 75

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:221635 Canovas J, et al., The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a. J Neurosci. 2015 May 13;35(19):7552-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory