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Gtf2b
Gene Detail
Symbol

Name
ID
Gtf2b
general transcription factor IIB
MGI:2385191
Synonyms
MGC:6859
Feature Type
protein coding gene
Genetic Map
Chromosome 3
66.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:142765247-142783606 bp, + strand
From NCBI annotation of GRCm38

  18360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1158  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription initiation factor IIB
Gene Tree: Gtf2b

Human
homologs
Human Homolog GTF2B, general transcription factor IIB
NCBI Gene ID 2959
neXtProt AC  NX_Q00403
Human Synonyms  TF2B, TFIIB
Human Chr (Location)  1p22-p21; chr1:88852638-88891618 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from APF )
Interactions
Gtf2b interacts with 110 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process DNA-templated transcription, initiation, regulation of transcription, DNA-templated, ...
Component nucleus
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (4)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
Western blot 3
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) cDNA(75)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000028271 (Evidence)
Entrez Gene229906 (Evidence)
UniGene271756
DFCITC1572859
DoTSDT.534439, DT.101390570
NIA Mouse Gene IndexU003927
Consensus CDS ProjectCCDS17882.1
International Mouse Knockout Project StatusGtf2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 229906 NCBI Gene Model | MGI Sequence Detail 18360 C57BL/6J ±  kb
transcript NM_145546 RefSeq | MGI Sequence Detail 1267 CZECHII 
polypeptide P62915 UniProt | EBI | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)    SNPs within 2kb including multiple locations(167)
Protein-related
information
ResourceIDDescription
InterPro IPR013763 Cyclin-like
InterPro IPR000812 Transcription factor TFIIB
InterPro IPR023486 Transcription factor TFIIB, conserved site
InterPro IPR013150 Transcription factor TFIIB, cyclin-like domain
InterPro IPR013137 Zinc finger, TFIIB-type
Protein Ontology PR:000008313 transcription initiation factor IIB
Graphical View of Protein Domain Structure
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory