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Clcc1 Gene Detail
Summary
  • Symbol
    Clcc1
  • Name
    chloride channel CLIC-like 1
  • Synonyms
    Mclc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385186
    NCBI Gene: 229725
  • Gene Overview
    MyGene.info: CLCC1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108653913-108678840 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 47.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385186
protein coding gene Chr3:108653878-108678840 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027783
protein coding gene Chr3:110224612-110252801 (+)
A/J MGP_AJ_G0027743
protein coding gene Chr3:106727034-106751883 (+)
AKR/J MGP_AKRJ_G0027708
protein coding gene Chr3:109317385-109343260 (+)
BALB/cJ MGP_BALBcJ_G0027755
protein coding gene Chr3:106423677-106448658 (+)
C3H/HeJ MGP_C3HHeJ_G0027485
protein coding gene Chr3:109677237-109702051 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028199
protein coding gene Chr3:114319758-114344713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025537
protein coding gene Chr3:102855301-102880461 (+)
CAST/EiJ MGP_CASTEiJ_G0026941
protein coding gene Chr3:109064861-109091922 (+)
CBA/J MGP_CBAJ_G0027460
protein coding gene Chr3:118226651-118259639 (+)
DBA/2J MGP_DBA2J_G0027602
protein coding gene Chr3:105898371-105923510 (+)
FVB/NJ MGP_FVBNJ_G0027570
protein coding gene Chr3:103787765-103814051 (+)
LP/J MGP_LPJ_G0027709
protein coding gene Chr3:111636689-111664333 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027600
protein coding gene Chr3:124270121-124296530 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028254
protein coding gene Chr3:108921815-108946604 (+)
PWK/PhJ MGP_PWKPhJ_G0026667
protein coding gene Chr3:105653854-105678976 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026487
protein coding gene Chr3:107062577-107091059 (+)
WSB/EiJ MGP_WSBEiJ_G0027021
protein coding gene Chr3:109456043-109482078 (+)



Homology
more
  • Human Ortholog
    CLCC1, chloride channel CLIC like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLCC1, chloride channel CLIC like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCLC
  • Links
    NCBI Gene ID: 23155
    neXtProt AC: NX_Q96S66
    UniProt: Q96S66

  • Chr Location
    1p13.3; chr1:108929508-108963499 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9032
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLCC1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation show strain-dependent cerebellar granule cell death and peripheral motor axon degeneration. The peripheral neuropathy, neurogenic muscular atrophy and mild truncal ataxia observed on the C57BL/6J background are not found on the C3H/HeSnJ background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027884 Ensembl Gene Model | MGI Sequence Detail 24928 C57BL/6J ±  kb
transcript ENSMUST00000106613 Ensembl | MGI Sequence Detail 3064 Not Applicable  
polypeptide ENSMUSP00000102224 Ensembl | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009231 Chloride channel CLIC-like
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 5
References
more
  • Summaries
    All 30
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:265914 Li L, et al., Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS Genet. 2018 Aug;14(8):e1007504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory