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Ahcyl1 Gene Detail
Summary
  • Symbol
    Ahcyl1
  • Name
    S-adenosylhomocysteine hydrolase-like 1
  • Synonyms
    1110034F20Rik, Ahcy-rs3, DCAL, IRBIT
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385184
    NCBI Gene: 229709
  • Gene Overview
    MyGene.info: AHCYL1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107663120-107696548 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385184
protein coding gene Chr3:107663118-107696560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027754
protein coding gene Chr3:109157512-109191496 (-)
A/J MGP_AJ_G0027714
protein coding gene Chr3:105706519-105739952 (-)
AKR/J MGP_AKRJ_G0027679
protein coding gene Chr3:108283211-108317642 (-)
BALB/cJ MGP_BALBcJ_G0027726
protein coding gene Chr3:105401498-105434903 (-)
C3H/HeJ MGP_C3HHeJ_G0027456
protein coding gene Chr3:108629950-108663483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028170
protein coding gene Chr3:113251255-113286198 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025508
protein coding gene Chr3:101861889-101895848 (-)
CAST/EiJ MGP_CASTEiJ_G0026912
protein coding gene Chr3:108005217-108042550 (-)
CBA/J MGP_CBAJ_G0027431
protein coding gene Chr3:117081314-117114759 (-)
DBA/2J MGP_DBA2J_G0027573
protein coding gene Chr3:104898920-104932349 (-)
FVB/NJ MGP_FVBNJ_G0027541
protein coding gene Chr3:102783156-102816636 (-)
LP/J MGP_LPJ_G0027680
protein coding gene Chr3:110589934-110623376 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027571
protein coding gene Chr3:123184409-123218599 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028225
protein coding gene Chr3:107875332-107909487 (-)
PWK/PhJ MGP_PWKPhJ_G0026638
protein coding gene Chr3:104640786-104674596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026458
protein coding gene Chr3:106004388-106035838 (-)
WSB/EiJ MGP_WSBEiJ_G0026992
protein coding gene Chr3:108404461-108437897 (-)



Homology
more
  • Human Ortholog
    AHCYL1, adenosylhomocysteinase like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AHCYL1, adenosylhomocysteinase like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA
  • Links
    NCBI Gene ID: 10768
    neXtProt AC: NX_O43865
    UniProt: O43865

  • Chr Location
    1p13.3; chr1:109984741-110023742 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormal exocrine pancreas physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229709 NCBI Gene Model | MGI Sequence Detail 33429 C57BL/6J ±  kb
    transcript NM_001357110 RefSeq | MGI Sequence Detail 3912 C57BL/6  
    polypeptide Q80SW1 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029742 S-adenosylhomocysteine hydrolase-like protein 1
    • InterPro Domains
      IPR000043 Adenosylhomocysteinase-like
      IPR036291 NAD(P)-binding domain superfamily
      IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site
      IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain
    Molecular
    Reagents
    less
    • All nucleic 187
      cDNA 185
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36379, MGI:107802, MGI:1353558, MGI:1920996, MGI:2139575
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:244730 Ando H, et al., IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Ialpha and IIalpha through Conserved Catalytic Aspartate Residues. PLoS One. 2015;10(10):e0141569

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory