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Ahcyl1 Gene Detail
Summary
  • Symbol
    Ahcyl1
  • Name
    S-adenosylhomocysteine hydrolase-like 1
  • Synonyms
    1110034F20Rik, Ahcy-rs3, DCAL, IRBIT
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385184
    NCBI Gene: 229709
  • Gene Overview
    MyGene.info: AHCYL1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:107663118-107696560 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33443 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AHCYL1, adenosylhomocysteinase like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AHCYL1, adenosylhomocysteinase like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA
  • Links
    NCBI Gene ID: 10768
    neXtProt AC: NX_O43865
    UniProt: O43865

  • Chr Location
    1p13.3; chr1:109984741-110023742 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormal exocrine pancreas physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029454 VEGA Gene Model | MGI Sequence Detail 33443 C57BL/6J ±  kb
    transcript OTTMUST00000072984 VEGA | MGI Sequence Detail 3863 Not Applicable  
    polypeptide OTTMUSP00000037720 VEGA | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      161 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029742 S-adenosylhomocysteine hydrolase-like protein 1
    • InterPro Domains
      IPR000043 Adenosylhomocysteinase-like
      IPR036291 NAD(P)-binding domain superfamily
      IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site
      IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain
    Molecular
    Reagents
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    • All nucleic 186
      cDNA 184
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36379, MGI:107802, MGI:1353558, MGI:1920996, MGI:2139575
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:244730 Ando H, et al., IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Ialpha and IIalpha through Conserved Catalytic Aspartate Residues. PLoS One. 2015;10(10):e0141569

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory