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Helz2 Gene Detail
Summary
  • Symbol
    Helz2
  • Name
    helicase with zinc finger 2, transcriptional coactivator
  • Synonyms
    BC006779, MGC:63178
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385169
    NCBI Gene: 229003
  • Gene Overview
    MyGene.info: HELZ2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:181227615-181242027 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385169
 protein coding gene Chr2:181227615-181242058 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027016
 protein coding gene Chr2:187804229-187818648 (-)
A/J MGP_AJ_G0026982
 protein coding gene Chr2:180078258-180092387 (-)
AKR/J MGP_AKRJ_G0026953
 protein coding gene Chr2:185472199-185486459 (-)
BALB/cJ MGP_BALBcJ_G0026991
 protein coding gene Chr2:180544001-180558708 (-)
C3H/HeJ MGP_C3HHeJ_G0026732
 protein coding gene Chr2:185829617-185844789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027437
 protein coding gene Chr2:193223538-193238649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024801
 protein coding gene Chr2:170762595-170777002 (-)
CAST/EiJ MGP_CASTEiJ_G0026191
 protein coding gene Chr2:184087168-184101529 (-)
CBA/J MGP_CBAJ_G0026709
 protein coding gene Chr2:200230428-200247899 (-)
DBA/2J MGP_DBA2J_G0026847
 protein coding gene Chr2:179171400-179185572 (-)
FVB/NJ MGP_FVBNJ_G0026813
 protein coding gene Chr2:177788168-177802580 (-)
LP/J MGP_LPJ_G0026948
 protein coding gene Chr2:187817084-187832839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026832
 protein coding gene Chr2:202796897-202811935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027496
 protein coding gene Chr2:185445003-185459406 (-)
PWK/PhJ MGP_PWKPhJ_G0025927
 protein coding gene Chr2:176696830-176711207 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025727
 protein coding gene Chr2:181929240-181947419 (-)
WSB/EiJ MGP_WSBEiJ_G0026263
 protein coding gene Chr2:186430052-186445810 (-)



Homology
more
  • Human Ortholog
    HELZ2, helicase with zinc finger 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HELZ2, helicase with zinc finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PDIP-1, PRIC285
  • Links
    NCBI Gene ID: 85441
    neXtProt AC: NX_Q9BYK8
    UniProt: Q9BYK8

  • Chr Location
    20q13.33; chr20:63558086-63574239 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit slower weight gain, hyperleptinemia, increased oxygen consumption, decreased respiratory quotient, decreased liver triglyceride level and ameliorated hyperlipidemia and hepatosteatosis when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    94
  • cDNA Data
    49
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027580 Ensembl Gene Model | MGI Sequence Detail 14413 C57BL/6J ±  kb
    transcript ENSMUST00000094203 Ensembl | MGI Sequence Detail 9162 Not Applicable  
    polypeptide ENSMUSP00000091756 Ensembl | MGI Sequence Detail 2970 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 49
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:218127 Yoshino S, et al., Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Endocrinology. 2014 Sep;155(9):3459-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/01/2019
    MGI 6.14     		The Jackson Laboratory