Slc35c2 MGI Mouse Gene Detail - MGI:2385166 - solute carrier family 35, member C2

Symbol

Slc35c2
Name

solute carrier family 35, member C2
Synonyms

CGI-15, D2Wsu58e, MGC:18664, Ovcov1

Feature Type

protein coding gene
IDs

MGI:2385166
NCBI Gene: 228875
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:165118474-165129789 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.53 cM
Mapping Data

3 experiments

SNPs within 2kb

739 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385166	protein coding gene	Chr2:165118442-165129808 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026889	protein coding gene	Chr2:170826068-170838518 (-)
A/J	MGP_AJ_G0026856	protein coding gene	Chr2:163824455-163838120 (-)
AKR/J	MGP_AKRJ_G0026827	protein coding gene	Chr2:168706383-168717706 (-)
BALB/cJ	MGP_BALBcJ_G0026865	protein coding gene	Chr2:164190376-164202209 (-)
C3H/HeJ	MGP_C3HHeJ_G0026607	protein coding gene	Chr2:169064960-169076983 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027312	protein coding gene	Chr2:175769638-175780791 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024683	protein coding gene	Chr2:157226751-157238059 (-)
CAST/EiJ	MGP_CASTEiJ_G0026065	protein coding gene	Chr2:169490664-169503850 (-)
CBA/J	MGP_CBAJ_G0026584	protein coding gene	Chr2:182166332-182177656 (-)
DBA/2J	MGP_DBA2J_G0026722	protein coding gene	Chr2:162985233-162996532 (-)
FVB/NJ	MGP_FVBNJ_G0026688	protein coding gene	Chr2:161427784-161439051 (-)
LP/J	MGP_LPJ_G0026824	protein coding gene	Chr2:170877382-170888666 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026707	protein coding gene	Chr2:185677958-185689229 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027369	protein coding gene	Chr2:168603785-168615109 (-)
PWK/PhJ	MGP_PWKPhJ_G0025802	protein coding gene	Chr2:162594843-162606400 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025603	protein coding gene	Chr2:167519553-167530719 (-)
WSB/EiJ	MGP_WSBEiJ_G0026138	protein coding gene	Chr2:169500318-169511625 (-)

Human Ortholog

SLC35H1, solute carrier family 35 member H1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC35H1, solute carrier family 35 member H1
Synonyms

BA394O2.1, C20orf5, CGI-15, OVCOV1, SLC35C2
Links

HGNC:17117

NCBI Gene ID: 51006

UniProt: Q9NQQ7
Chr Location

20q13.12; chr20:46345980-46364458 (-) GRCh38

MGI Vertebrate Homology

Slc35c2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC35H1
Gene Tree

Slc35c2

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation are viable and fertile with no gross abnormalities.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

145
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc35c2

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All Sequences

114
RefSeq

32
UniProt

11
CCDS

CCDS17074.1

Ensembl

ENSMUSG00000017664 (Evidence)
NCBI Gene

228875

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017664	Ensembl Gene Model \| MGI Sequence Detail	11316	C57BL/6J	± kb
transcript	ENSMUST00000017808	Ensembl \| MGI Sequence Detail	1843	Not Applicable
polypeptide	ENSMUSP00000017808	Ensembl \| MGI Sequence Detail	364	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000015097 solute carrier family 35 member C2

(term hierarchy)
InterPro Domains

IPR004853 Sugar phosphate transporter domain

IPR050186 Triose Phosphate/Phosphate Translocator
GlyGen

Q8VCX2 1 site

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 6

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MGD-MRK-34239, MGI:106545, MGI:2139522

Summaries

All 43

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 10
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc35c2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27616	Chr2:165129773-165129783 (-)	11 bp
Tssr27615	Chr2:165129722-165129765 (-)	45 bp
Tssr27614	Chr2:165128833-165128853 (-)	946 bp
Tssr27613	Chr2:165128463-165128480 (-)	1,317 bp
Tssr27612	Chr2:165125688-165125709 (-)	4,090 bp
Tssr27611	Chr2:165125631-165125645 (-)	4,151 bp
Tssr27610	Chr2:165125576-165125603 (-)	4,199 bp
Tssr27609	Chr2:165125568-165125575 (-)	4,217 bp
Tssr27608	Chr2:165125519-165125540 (-)	4,259 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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