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Exosc2 Gene Detail
Summary
  • Symbol
    Exosc2
  • Name
    exosome component 2
  • Synonyms
    Rrp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385133
    NCBI Gene: 227715
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31560727-31571361 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385133
protein coding gene Chr2:31560727-31571593 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025588
protein coding gene Chr2:30029134-30040180 (+)
A/J MGP_AJ_G0025566
protein coding gene Chr2:28790063-28800488 (+)
AKR/J MGP_AKRJ_G0025535
protein coding gene Chr2:29765614-29779675 (+)
BALB/cJ MGP_BALBcJ_G0025562
protein coding gene Chr2:28918960-28929512 (+)
C3H/HeJ MGP_C3HHeJ_G0025323
protein coding gene Chr2:29695634-29708236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026007
protein coding gene Chr2:30971216-30983457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023415
protein coding gene Chr2:27545952-27556861 (+)
CAST/EiJ MGP_CASTEiJ_G0024785
protein coding gene Chr2:29641032-29652435 (+)
CBA/J MGP_CBAJ_G0025300
protein coding gene Chr2:32082740-32094766 (+)
DBA/2J MGP_DBA2J_G0025433
protein coding gene Chr2:28563442-28574525 (+)
FVB/NJ MGP_FVBNJ_G0025396
protein coding gene Chr2:28422794-28433268 (+)
LP/J MGP_LPJ_G0025519
protein coding gene Chr2:29918803-29929708 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025426
protein coding gene Chr2:31834322-31850312 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026065
protein coding gene Chr2:29692244-29703750 (+)
PWK/PhJ MGP_PWKPhJ_G0024532
protein coding gene Chr2:28463144-28474203 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024332
protein coding gene Chr2:29840558-29850652 (+)
WSB/EiJ MGP_WSBEiJ_G0024853
protein coding gene Chr2:29863749-29875175 (+)



Homology
more
  • Human Ortholog
    EXOSC2, exosome component 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOSC2, exosome component 2
  • Synonyms
    hRrp4p, p7, RRP4, Rrp4p, SHRF
  • Links
    NCBI Gene ID: 23404
    neXtProt AC: NX_Q13868
    UniProt: Q13868

  • Chr Location
    9q34.12; chr9:130693760-130704894 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039356 Ensembl Gene Model | MGI Sequence Detail 10635 C57BL/6J ±  kb
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:302538 Ulmke PA, et al., Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Development. 2021 Feb 8;148(3):dev188276

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/17/2022
    MGI 6.19
    The Jackson Laboratory