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Lrrc26 Gene Detail
Summary
  • Symbol
    Lrrc26
  • Name
    leucine rich repeat containing 26
  • Synonyms
    MGC:37548, MGC:37592, MGC:6965
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385129
    NCBI Gene: 227618
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25289915-25291180 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385129
protein coding gene Chr2:25289911-25291193 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025437
protein coding gene Chr2:23157786-23159051 (+)
A/J MGP_AJ_G0025414
protein coding gene Chr2:22269207-22270472 (+)
AKR/J MGP_AKRJ_G0025384
protein coding gene Chr2:23014657-23015922 (+)
BALB/cJ MGP_BALBcJ_G0025410
protein coding gene Chr2:22380396-22381661 (+)
C3H/HeJ MGP_C3HHeJ_G0025171
protein coding gene Chr2:22940378-22941643 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025854
protein coding gene Chr2:23892512-23893777 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023265
protein coding gene Chr2:21185373-21186640 (+)
CAST/EiJ MGP_CASTEiJ_G0024635
protein coding gene Chr2:22823849-22825114 (+)
CBA/J MGP_CBAJ_G0025149
protein coding gene Chr2:24729528-24730793 (+)
DBA/2J MGP_DBA2J_G0025282
protein coding gene Chr2:22110807-22112072 (+)
FVB/NJ MGP_FVBNJ_G0025244
protein coding gene Chr2:21851790-21853055 (+)
LP/J MGP_LPJ_G0025368
protein coding gene Chr2:23102325-23103590 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025275
protein coding gene Chr2:24930413-24931678 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025913
protein coding gene Chr2:22960694-22961959 (+)
PWK/PhJ MGP_PWKPhJ_G0024383
protein coding gene Chr2:21924007-21925272 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024183
protein coding gene Chr2:23115370-23116635 (+)
WSB/EiJ MGP_WSBEiJ_G0024703
protein coding gene Chr2:23031219-23032484 (+)



Homology
more
  • Human Ortholog
    LRRC26, leucine rich repeat containing 26
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LRRC26, leucine rich repeat containing 26
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA350O14.10, CAPC
  • Links
    NCBI Gene ID: 389816
    neXtProt AC: NX_Q2I0M4
    UniProt: Q2I0M4

  • Chr Location
    9q34.3; chr9:137168758-137170039 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The gene product is part of BK ion channels in secretory epithelial cells. Homozygous knockout results in significantly reduced K+ efflux from salivary glands.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026961 Ensembl Gene Model | MGI Sequence Detail 1266 C57BL/6J ±  kb
transcript ENSMUST00000028337 Ensembl | MGI Sequence Detail 1190 Not Applicable  
polypeptide ENSMUSP00000028337 Ensembl | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:242233 Yang C, et al., Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells. Proc Natl Acad Sci U S A. 2017 May 02;114(18):E3739-E3747

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory