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Farp2
Gene Detail
 Symbol
Name
ID
Farp2
FERM, RhoGEF and pleckstrin domain protein 2
MGI:2385126
Synonyms D030026M03Rik, Fir
Feature Type protein coding gene
Genetic Map
Chromosome 1
47.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:93512079-93621976 bp, + strand
From VEGA annotation of GRCm38

  109898 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Farp2

Human
homologs
Human Homolog FARP2, FERM, RhoGEF and pleckstrin domain protein 2
NCBI Gene ID 9855
neXtProt AC  NX_O94887
Human Synonyms  FIR, FRG, PLEKHC3
Human Chr (Location)  2q37.3; chr2:241356249-241495074 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL
 
Interactions
Farp2 interacts with 139 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin cytoskeleton reorganization, cell adhesion, ...
Component cytoplasm, cytoskeleton, ...
Function cytoskeletal protein binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (32)    Tissues (31)    Images (11)
Theiler Stages: 19, 21, 23, 25, 28
Assay TypeResults
RNA in situ 26
Northern blot 6
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026441 (Evidence)
Ensembl Gene ModelENSMUSG00000034066 (Evidence)
Entrez Gene227377 (Evidence)
UniGene243091
DFCITC1578281, TC1615763, TC1678782
NIA Mouse Gene IndexU000633
PDB4GYV, 4GZU
Consensus CDS ProjectCCDS15191.1
International Mouse Knockout Project StatusFarp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026441 VEGA Gene Model | MGI Sequence Detail 109898 C57BL/6J ±  kb
transcript OTTMUST00000065398 VEGA | MGI Sequence Detail 3938 Not Applicable 
polypeptide OTTMUSP00000032592 VEGA | MGI Sequence Detail 1065 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(594 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019750 Band 4.1 family
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR000798 Ezrin/radixin/moesin like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR014847 FERM adjacent (FA)
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007344 FERM, RhoGEF and pleckstrin domain-containing protein 2
References (Earliest) J:79193 Kubo T, et al., A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J Neurosci. 2002 Oct 1;22(19):8504-13
(Latest) J:196400 He X, et al., Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. Structure. 2013 Mar 5;21(3):355-64
All references(38)
Other
accession IDs
MGI:2138267, MGI:2444756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory