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Farp2
Gene Detail
Symbol

Name
ID
Farp2
FERM, RhoGEF and pleckstrin domain protein 2
MGI:2385126
Synonyms
D030026M03Rik, Fir
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:93512079-93621976 bp, + strand
From VEGA annotation of GRCm38

  109898 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: FARP2
Gene Tree: Farp2

Human
homologs
FARP2, FERM, RhoGEF and pleckstrin domain protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9855
neXtProt AC: NX_O94887

Human Synonyms: FIR, FRG, PLEKHC3

Human Chr (Location): 2q37.3; chr2:241356249-241494842 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL
 
Interactions
Farp2 interacts with 138 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin cytoskeleton reorganization, cell adhesion, ...
Component cytoplasm, cytoskeleton, ...
Function cytoskeletal protein binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (32)    Tissues (31)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
Northern blot 6
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FARP2 ; Xenbase farp2    NEW 
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026441 (Evidence)
Ensembl Gene Model ENSMUSG00000034066 (Evidence)
Entrez Gene 227377 (Evidence)
UniGene 243091
DFCI TC1678782, TC1615763, TC1578281
NIA Mouse Gene Index U000633
PDB 4GYV, 4GZU
Consensus CDS Project CCDS15191.1
International Mouse Phenotyping Consortium Status Farp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026441 VEGA Gene Model | MGI Sequence Detail 109898 C57BL/6J ±  kb
transcript OTTMUST00000065398 VEGA | MGI Sequence Detail 3937 Not Applicable 
polypeptide OTTMUSP00000032592 VEGA | MGI Sequence Detail 1065 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(594 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR000798 Ezrin/radixin/moesin like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR014847 FERM adjacent (FA)
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007344 FERM, RhoGEF and pleckstrin domain-containing protein 2
References
(Earliest) J:79193 Kubo T, et al., A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J Neurosci. 2002 Oct 1;22(19):8504-13
(Latest) J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540
All references(38)
Other
accession IDs
MGI:2138267, MGI:2444756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory