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Pprc1 Gene Detail
Summary
  • Symbol
    Pprc1
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator-related 1
  • Synonyms
    MGC:12121, mKIAA0595
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385096
    NCBI Gene: 226169
  • Gene Overview
    MyGene.info: PPRC1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46056525-46072909 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385096
protein coding gene Chr19:46044886-46072915 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025198
protein coding gene Chr19:45703557-45735137 (+)
A/J MGP_AJ_G0025174
protein coding gene Chr19:43457420-43485809 (+)
AKR/J MGP_AKRJ_G0025143
protein coding gene Chr19:44862470-44894142 (+)
BALB/cJ MGP_BALBcJ_G0025169
protein coding gene Chr19:43513308-43540890 (+)
C3H/HeJ MGP_C3HHeJ_G0024929
protein coding gene Chr19:45036020-45064447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025612
protein coding gene Chr19:46841109-46871125 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023026
protein coding gene Chr19:42693525-42725594 (+)
CAST/EiJ MGP_CASTEiJ_G0024394
protein coding gene Chr19:44805983-44840421 (+)
CBA/J MGP_CBAJ_G0024909
protein coding gene Chr19:49198186-49234415 (+)
DBA/2J MGP_DBA2J_G0025041
protein coding gene Chr19:43275642-43306315 (+)
FVB/NJ MGP_FVBNJ_G0025002
protein coding gene Chr19:43051551-43080765 (+)
LP/J MGP_LPJ_G0025127
protein coding gene Chr19:45613033-45643463 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025033
protein coding gene Chr19:48560146-48589240 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025670
protein coding gene Chr19:44970421-45001068 (+)
PWK/PhJ MGP_PWKPhJ_G0024143
protein coding gene Chr19:43206431-43236088 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023947
protein coding gene Chr19:43625919-43659488 (+)
WSB/EiJ MGP_WSBEiJ_G0024464
protein coding gene Chr19:45115582-45143720 (+)



Homology
more
  • Human Ortholog
    PPRC1, peroxisome proliferator-activated receptor gamma, coactivator-related 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PPRC1, peroxisome proliferator-activated receptor gamma, coactivator-related 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRC
  • Links
    NCBI Gene ID: 23082
    neXtProt AC: NX_Q5VV67
    UniProt: Q5VV67

  • Chr Location
    10q24.32; chr10:102132994-102150333 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit letahlity post-implantation with delayed hatching and disorganized embryo tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226169 NCBI Gene Model | MGI Sequence Detail 16385 C57BL/6J ±  kb
    transcript NM_001346801 RefSeq | MGI Sequence Detail 5250 C57BL/6  
    polypeptide Q6NZN1 UniProt | EBI | MGI Sequence Detail 1644 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013159 peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034605 PGC-1
      IPR034597 PGC-1-related coactivator
      IPR034834 PGC-1-related coactivator, RNA recognition motif
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 118
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:244174 Alkaissi H, et al., Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Environ Health Perspect. 2016 Jul;124(7):920-6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory