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Smc5 Gene Detail
Summary
  • Symbol
    Smc5
  • Name
    structural maintenance of chromosomes 5
  • Synonyms
    MGC:7569, Smc5l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385088
    NCBI Gene: 226026
  • Gene Overview
    MyGene.info: SMC5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:23206441-23273897 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67457 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 18.04 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SMC5, structural maintenance of chromosomes 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMC5, structural maintenance of chromosomes 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMC5L1
  • Links
    NCBI Gene ID: 23137
    neXtProt AC: NX_Q8IY18
    UniProt: Q8IY18

  • Chr Location
    9q21.12; chr9:70258962-70354873 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41009
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMC5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout in embryonic stem cells causes abnormal mitosis, increased apoptosis and a shift from pluripotency to differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024943 Ensembl Gene Model | MGI Sequence Detail 67457 C57BL/6J ±  kb
transcript ENSMUST00000087556 Ensembl | MGI Sequence Detail 5730 Not Applicable  
polypeptide ENSMUSP00000084837 Ensembl | MGI Sequence Detail 1087 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    663 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015274 structural maintenance of chromosomes protein 5
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR003395 RecF/RecN/SMC, N-terminal
    IPR027131 Structural maintenance of chromosomes protein 5
Molecular
Reagents
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  • All nucleic 132
    cDNA 132

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:162301 Taylor EM, et al., Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. Mol Biol Cell. 2001 Jun;12(6):1583-94
  • Latest
    J:241574 Hwang G, et al., SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 2017 May 01;144(9):1648-1660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory