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Smc5 Gene Detail
Summary
  • Symbol
    Smc5
  • Name
    structural maintenance of chromosomes 5
  • Synonyms
    MGC:7569, Smc5l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385088
    NCBI Gene: 226026
  • Gene Overview
    MyGene.info: SMC5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:23206451-23273897 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 18.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    663 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385088
protein coding gene Chr19:23206441-23273914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024984
protein coding gene Chr19:21340611-21415450 (-)
A/J MGP_AJ_G0024961
protein coding gene Chr19:20171887-20240749 (-)
AKR/J MGP_AKRJ_G0024931
protein coding gene Chr19:20945023-21019772 (-)
BALB/cJ MGP_BALBcJ_G0024960
protein coding gene Chr19:20215346-20285900 (-)
C3H/HeJ MGP_C3HHeJ_G0024718
protein coding gene Chr19:20907905-20985630 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025402
protein coding gene Chr19:22028092-22109490 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022821
protein coding gene Chr19:20358714-20426979 (-)
CAST/EiJ MGP_CASTEiJ_G0024186
protein coding gene Chr19:20620162-20698522 (-)
CBA/J MGP_CBAJ_G0024696
protein coding gene Chr19:22960298-23046923 (-)
DBA/2J MGP_DBA2J_G0024828
protein coding gene Chr19:20190812-20261198 (-)
FVB/NJ MGP_FVBNJ_G0024789
protein coding gene Chr19:20041817-20115669 (-)
LP/J MGP_LPJ_G0024912
protein coding gene Chr19:21287566-21365167 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0025457
protein coding gene Chr19:20938972-21014504 (-)
PWK/PhJ MGP_PWKPhJ_G0023935
protein coding gene Chr19:19761297-19836977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023740
protein coding gene Chr19:20134688-20224055 (-)
WSB/EiJ MGP_WSBEiJ_G0024254
protein coding gene Chr19:20956501-21031498 (-)



Homology
more
  • Human Ortholog
    SMC5, structural maintenance of chromosomes 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMC5, structural maintenance of chromosomes 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMC5L1
  • Links
    NCBI Gene ID: 23137
    neXtProt AC: NX_Q8IY18
    UniProt: Q8IY18

  • Chr Location
    9q21.12; chr9:70258962-70354873 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41009
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMC5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout in embryonic stem cells causes abnormal mitosis, increased apoptosis and a shift from pluripotency to differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024943 Ensembl Gene Model | MGI Sequence Detail 67447 C57BL/6J ±  kb
transcript ENSMUST00000087556 Ensembl | MGI Sequence Detail 5683 Not Applicable  
polypeptide ENSMUSP00000084837 Ensembl | MGI Sequence Detail 1101 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015274 structural maintenance of chromosomes protein 5
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR003395 RecF/RecN/SMC, N-terminal
    IPR027131 Structural maintenance of chromosomes protein 5
Molecular
Reagents
less
  • All nucleic 133
    cDNA 133

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:162301 Taylor EM, et al., Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. Mol Biol Cell. 2001 Jun;12(6):1583-94
  • Latest
    J:241574 Hwang G, et al., SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 2017 May 01;144(9):1648-1660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory