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Ndufs8 Gene Detail
Summary
  • Symbol
    Ndufs8
  • Name
    NADH dehydrogenase (ubiquinone) Fe-S protein 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385079
    NCBI Gene: 225887
  • Gene Overview
    MyGene.info: NDUFS8
Location & Maps
more
  • Sequence Map
    Chr19:3908870-3912717 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3848 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NDUFS8, NADH:ubiquinone oxidoreductase core subunit S8
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NDUFS8, NADH:ubiquinone oxidoreductase core subunit S8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CI-23k, CI23KD, TYKY
  • Links
    NCBI Gene ID: 4728
    neXtProt AC: NX_O00217

  • Chr Location
    11q13; chr11:68030617-68036647 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NDUFS8 associations

Human Disease Mouse Models
       Leigh Syndrome; LS   OMIM: 256000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    28
  • Endonuclease-mediated
    1
  • Gene trapped
    27
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059734 Ensembl Gene Model | MGI Sequence Detail 3848 C57BL/6J ±  kb
transcript ENSMUST00000075092 Ensembl | MGI Sequence Detail 963 Not Applicable  
polypeptide ENSMUSP00000074600 Ensembl | MGI Sequence Detail 212 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011103 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
  • EC
  • InterPro Domains
    IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
    IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
    IPR010226 NADH-quinone oxidoreductase, chain I
Molecular
Reagents
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  • All nucleic 84
    cDNA 84

    Microarray probesets 8
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory