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Ndufs8
Gene Detail
 Symbol
Name
ID
Ndufs8
NADH dehydrogenase (ubiquinone) Fe-S protein 8
MGI:2385079
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:3908870-3912717 bp, - strand
From NCBI annotation of GRCm38

  3848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: NADH-ubiquinone oxidoreductase 23 kDa subunit
Gene Tree: Ndufs8

Human
homologs
Human Homolog NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NCBI Gene ID 4728
neXtProt AC  NX_O00217
Human Synonyms  CI-23k, CI23KD, TYKY
Human Chr (Location)  11q13; chr11:68030617-68036647 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NDUFS8
Alleles
and
phenotypes
All alleles(27) : Gene trapped(27)
Incidental mutations (data from APF )
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process mitochondrial respiratory chain complex I assembly, oxidation-reduction process, ...
Component membrane, mitochondrial respiratory chain complex I, ...
Function 4 iron, 4 sulfur cluster binding, iron-sulfur cluster binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(84)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(84) cDNA(84)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000059734 (Evidence)
Entrez Gene225887 (Evidence)
UniGene44227
DFCITC1574384, TC1668055, TC1723687, TC1770163
DoTSDT.94192207, DT.94192216, DT.94313318, DT.97390211, DT.99873261
NIA Mouse Gene IndexU019109
EC1.6.5.3, 1.6.99.3
Consensus CDS ProjectCCDS29402.1
International Mouse Knockout Project StatusNdufs8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 225887 NCBI Gene Model | MGI Sequence Detail 3848 C57BL/6J ±  kb
transcript NM_144870 RefSeq | MGI Sequence Detail 1057 Not Specified 
polypeptide Q8K3J1 UniProt | EBI | MGI Sequence Detail 212 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001450 4Fe-4S binding domain
InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulpur binding domain
InterPro IPR010226 NADH-quinone oxidoreductase, chain I
Protein Ontology PR:000011103 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:50639 Schibler L, et al., Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans. Genome Res. 1998 Sep;8(9):901-15
(Latest) J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory