Ndufs8
Gene Detail

Symbol Name ID

Ndufs8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 MGI:2385079

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:3908870-3912717 bp, - strand From NCBI annotation of GRCm38   3848 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: NADH-ubiquinone oxidoreductase 23 kDa subunit
Gene Tree: Ndufs8

Human homologs

Human Homolog		NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NCBI Gene ID		4728
neXtProt AC		NX_O00217
Human Synonyms		CI-23k, CI23KD, TYKY
Human Chr (Location)		11q13; chr11:67798084-67804114 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NDUFS8

Alleles and phenotypes

All alleles(27) : Gene trapped(27)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	electron transport chain, mitochondrial respiratory chain complex I assembly, ...
Component	membrane, mitochondrial respiratory chain complex I, ...
Function	4 iron, 4 sulfur cluster binding, electron carrier activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000059734 (Evidence)
Entrez Gene	225887 (Evidence)
DFCI	TC1574384, TC1668055, TC1723687, TC1770163
DoTS	DT.94192207, DT.94192216, DT.94313318, DT.97390211, DT.99873261
NIA Mouse Gene Index	U019109
EC	1.6.5.3, 1.6.99.3
Consensus CDS Project	CCDS29402.1
International Mouse Knockout Project Status	Ndufs8

Sequences

Length	Strain/Species
genomic	225887	NCBI Gene Model | MGI Sequence Detail	3848	C57BL/6J
transcript	NM_144870	RefSeq | MGI Sequence Detail	1057	Not Specified
polypeptide	Q8K3J1	UniProt | EBI | MGI Sequence Detail	212	Not Applicable

All sequences(40) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001450	4Fe-4S binding domain
InterPro	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulpur binding domain
InterPro	IPR012285	Fumarate reductase, C-terminal
InterPro	IPR010226	NADH-quinone oxidoreductase, chain I
Protein Ontology	PR:000011103	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:50639 Schibler L, et al., Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans. Genome Res. 1998 Sep;8(9):901-15
(Latest) J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897
All references(32)