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Reep2 Gene Detail
Summary
  • Symbol
    Reep2
  • Name
    receptor accessory protein 2
  • Synonyms
    MGC:28827
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385070
    NCBI Gene: 225362
  • Gene Overview
    MyGene.info: REEP2
Location & Maps
more
  • Sequence Map
    Chr18:34840589-34847463 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6875 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    REEP2, receptor accessory protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    REEP2, receptor accessory protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C5orf19, SGC32445, SPG72, Yip2d
  • Links
    NCBI Gene ID: 51308
    neXtProt AC: NX_Q9BRK0

  • Chr Location
    5q31; chr5:138439001-138446969 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41146
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: REEP2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human REEP2 associations

Human Disease Mouse Models
       Spastic Paraplegia 72, Autosomal Recessive; SPG72   OMIM: 615625
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    2
  • Gene trapped
    1
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 225362 NCBI Gene Model | MGI Sequence Detail 6875 C57BL/6J ±  kb
transcript NM_144865 RefSeq | MGI Sequence Detail 1926 C57BL/6  
polypeptide Q8VCD6 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    21 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013864 receptor expression-enhancing protein 2
  • InterPro Domains
    IPR004345 TB2/DP1/HVA22-related protein
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147414
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:212061 Bjork S, et al., REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. PLoS One. 2013;8(10):e76366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory