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Lims2
Gene Detail
Symbol

Name
ID
Lims2
LIM and senescent cell antigen like domains 2
MGI:2385067
Synonyms
PINCH2
Feature Type
protein coding gene
Genetic Map
Chromosome 18
17.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:31931507-31958619 bp, + strand
From Ensembl annotation of GRCm38

  27113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: LIMS2
Protein SuperFamily: PINCH protein
Gene Tree: Lims2

Human
homologs
LIMS2, LIM and senescent cell antigen-like domains 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55679
neXtProt AC: NX_Q7Z4I7

Human Synonyms: PINCH2, PINCH-2

Human Chr (Location): 2q14.3; chr2:127638421-127681786 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile with no gross abnormalities. Mice homozygous for a different targeted allele exhibit decreased fractional shortening and increased area affected following myocardial infarct.
 
Interactions
Lims2 interacts with 66 markers (Mir17, Mir20b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell-cell junction organization, negative regulation of apoptotic process, ...
Component cell junction, focal adhesion, ...
Function metal ion binding, zinc ion binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (78)    Tissues (76)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
RT-PCR 8
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN lims2    NEW 
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024395 (Evidence)
Entrez Gene 225341 (Evidence)
UniGene 24551
DFCI TC1580913
DoTS DT.492565
NIA Mouse Gene Index U018514
Consensus CDS Project CCDS29113.1
International Mouse Phenotyping Consortium Status Lims2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024395 Ensembl Gene Model | MGI Sequence Detail 27113 C57BL/6J ±  kb
transcript ENSMUST00000025254 Ensembl | MGI Sequence Detail 1688 Not Applicable 
polypeptide ENSMUSP00000025254 Ensembl | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017351 PINCH
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009819 LIM and senescent cell antigen-like-containing domain protein 2
References
(Earliest) J:82868 Braun A, et al., PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003 Apr 1;284(2):239-50
(Latest) J:208403 Boudoukha S, et al., MiRNA let-7g regulates skeletal myoblast motility via Pinch-2. FEBS Lett. 2014 May 2;588(9):1623-9
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory