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Pex6 Gene Detail
Summary
  • Symbol
    Pex6
  • Name
    peroxisomal biogenesis factor 6
  • Synonyms
    D130055I09Rik, MGC:6455
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385054
    NCBI Gene: 224824
  • Gene Overview
    MyGene.info: PEX6
Location & Maps
more
  • Sequence Map
    Chr17:46711463-46725541 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14079 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PEX6, peroxisomal biogenesis factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX6, peroxisomal biogenesis factor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HMLR2, PAF2, PAF-2, PBD4A, PDB4B, PXAAA1
  • Links
    NCBI Gene ID: 5190
    neXtProt AC: NX_Q13608

  • Chr Location
    6p21.1; chr6:42963873-42979243 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 47914
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PEX6
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with human PEX6 associations

Human Disease Mouse Models
       Heimler Syndrome 2; HMLR2   OMIM: 616617
Peroxisome Biogenesis Disorder 4a (zellweger); PBD4A   OMIM: 614862
Peroxisome Biogenesis Disorder 4b; PBD4B   OMIM: 614863
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026320 VEGA Gene Model | MGI Sequence Detail 14079 C57BL/6J ±  kb
transcript OTTMUST00000065100 VEGA | MGI Sequence Detail 3200 Not Applicable  
polypeptide OTTMUSP00000032402 VEGA | MGI Sequence Detail 981 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012567 peroxisome assembly factor 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003960 ATPase, AAA-type, conserved site
    IPR003959 ATPase, AAA-type, core
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGI:2146801, MGI:2445130
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory