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Slc26a8
Gene Detail
Symbol

Name
ID
Slc26a8
solute carrier family 26, member 8
MGI:2385046
Synonyms
MGC:38861
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:28637783-28689987 bp, - strand
From VEGA annotation of GRCm38

  52205 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slc26a8

Human
homologs
Human Homolog SLC26A8, solute carrier family 26 (anion exchanger), member 8
NCBI Gene ID 116369
neXtProt AC  NX_Q96RN1
Human Synonyms  SPGF3, TAT1
Human Chr (Location)  6p21; chr6:35943514-36028898 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC26A8
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit male sterility associated with sperm immotility, abnormal flagella and reduced acrosomal reaction.
 
Interactions
Slc26a8 interacts with 78 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process anion transport, cell differentiation, ...
Component integral component of membrane, membrane, ...
Function anion:anion antiporter activity, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024246 (Evidence)
Ensembl Gene ModelENSMUSG00000036196 (Evidence)
Entrez Gene224661 (Evidence)
UniGene219530
DFCITC1590529, TC1671340
DoTSDT.40144663, DT.97352895
NIA Mouse Gene IndexU037613
Consensus CDS ProjectCCDS28582.1, CCDS70779.1
International Mouse Knockout Project StatusSlc26a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024246 VEGA Gene Model | MGI Sequence Detail 52205 C57BL/6J ±  kb
transcript OTTMUST00000059341 VEGA | MGI Sequence Detail 3670 Not Applicable 
polypeptide OTTMUSP00000028858 VEGA | MGI Sequence Detail 999 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(27) UniProt(1)
Polymorphisms
SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002645 STAS domain
InterPro IPR011547 Sulphate transporter
Protein Ontology PR:000015043 testis anion transporter 1
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:181151 Rode B, et al., The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation. Hum Mol Genet. 2012 Mar 15;21(6):1287-98
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory