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Slc26a8 Gene Detail
Summary
  • Symbol
    Slc26a8
  • Name
    solute carrier family 26, member 8
  • Synonyms
    MGC:38861
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385046
    NCBI Gene: 224661
  • Gene Overview
    MyGene.info: SLC26A8
Location & Maps
more
  • Sequence Map
    Chr17:28637783-28689987 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52205 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC26A8, solute carrier family 26 member 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC26A8, solute carrier family 26 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPGF3, TAT1
  • Links
    NCBI Gene ID: 116369
    neXtProt AC: NX_Q96RN1

  • Chr Location
    6p21.31; chr6:35943514-36024636 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC26A8 associations

Human Disease Mouse Models
       Spermatogenic Failure 3; SPGF3   OMIM: 606766
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    16
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit male sterility associated with sperm immotility, abnormal flagella and reduced acrosomal reaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024246 VEGA Gene Model | MGI Sequence Detail 52205 C57BL/6J ±  kb
transcript OTTMUST00000059341 VEGA | MGI Sequence Detail 3670 Not Applicable  
polypeptide OTTMUSP00000028858 VEGA | MGI Sequence Detail 999 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    170 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:181151 Rode B, et al., The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation. Hum Mol Genet. 2012 Mar 15;21(6):1287-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory