Alg12
Gene Detail

Symbol Name ID

Alg12 asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase) MGI:2385025

Synonyms

ECM39, mannosyltransferase, MGC:29374

Feature Type

protein coding gene

Genetic Map

Chromosome 15

44.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:88805244-88819318 bp, - strand From VEGA annotation of GRCm38   14075 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36269  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alg12

Human homologs

Human Homolog		ALG12, ALG12, alpha-1,6-mannosyltransferase
NCBI Gene ID		79087
neXtProt AC		NX_Q9BV10
Human Synonyms		CDG1G, ECM39, hALG12, PP14673
Human Chr (Location)		22q13.33; chr22:50296852-50312106 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALG12

Alleles and phenotypes

All alleles(19) : Targeted(3) Gene trapped(16)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	dolichol-linked oligosaccharide biosynthetic process, GPI anchor biosynthetic process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity, mannosyltransferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031154 (Evidence)
Ensembl Gene Model	ENSMUSG00000035845 (Evidence)
Entrez Gene	223774 (Evidence)
UniGene	41512
DFCI	TC1584549, TC1589388
DoTS	DT.101365428, DT.527780
NIA Mouse Gene Index	U036514
EC	2.4.1.260
Consensus CDS Project	CCDS27732.1, CCDS49694.1
International Mouse Knockout Project Status	Alg12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031154	VEGA Gene Model | MGI Sequence Detail	14075	C57BL/6J
transcript	OTTMUST00000077174	VEGA | MGI Sequence Detail	2130	Not Applicable
polypeptide	OTTMUSP00000040753	VEGA | MGI Sequence Detail	486	Not Applicable

All sequences(37) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005599	GPI mannosyltransferase
Protein Ontology	PR:000003940	dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase

References

(Earliest) J:77825 Chantret I, et al., Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. J Biol Chem. 2002 Jul 12;277(28):25815-22
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)