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Fermt2 Gene Detail
Summary
  • Symbol
    Fermt2
  • Name
    fermitin family member 2
  • Synonyms
    Kindlin-2, Mig2, Plekhc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385001
    NCBI Gene: 218952
  • Gene Overview
    MyGene.info: FERMT2
Location & Maps
more
  • Sequence Map
    Chr14:45458792-45530118 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71327 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FERMT2, fermitin family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FERMT2, fermitin family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIND2, mig-2, MIG2, PLEKHC1, UNC112, UNC112B
  • Links
    NCBI Gene ID: 10979
    neXtProt AC: NX_Q96AC1

  • Chr Location
    14q22.1; chr14:52857271-52951097 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4976
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FERMT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 4 alleles in 6 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    84
  • Chemically induced (other)
    1
  • Gene trapped
    78
  • Targeted
    5
  • Genomic Mutations
    1 involving Fermt2
  • Incidental Mutations
Homozygous mice are embryonic lethal at or before E7.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026135 VEGA Gene Model | MGI Sequence Detail 71327 C57BL/6J ±  kb
transcript OTTMUST00000064548 VEGA | MGI Sequence Detail 3296 Not Applicable  
polypeptide OTTMUSP00000032080 VEGA | MGI Sequence Detail 680 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    338 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 157
    cDNA 154
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2145587
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:230650 Theodosiou M, et al., Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory