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Fermt2 Gene Detail
Summary
  • Symbol
    Fermt2
  • Name
    fermitin family member 2
  • Synonyms
    Kindlin-2, Mig2, Plekhc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385001
    NCBI Gene: 218952
  • Gene Overview
    MyGene.info: FERMT2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45458792-45530113 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385001
protein coding gene Chr14:45458792-45530118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021209
protein coding gene Chr14:39087551-39162769 (-)
A/J MGP_AJ_G0021156
protein coding gene Chr14:37942650-38014392 (-)
AKR/J MGP_AKRJ_G0021134
protein coding gene Chr14:39419799-39499692 (-)
BALB/cJ MGP_BALBcJ_G0021160
protein coding gene Chr14:37981134-38054192 (-)
C3H/HeJ MGP_C3HHeJ_G0020943
protein coding gene Chr14:39223087-39297861 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021594
protein coding gene Chr14:40788327-40873481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019153
protein coding gene Chr14:37349842-37420789 (-)
CAST/EiJ MGP_CASTEiJ_G0020468
protein coding gene Chr14:36339974-36416278 (-)
CBA/J MGP_CBAJ_G0020909
protein coding gene Chr14:42100467-42176228 (-)
DBA/2J MGP_DBA2J_G0021032
protein coding gene Chr14:37849218-37921257 (-)
FVB/NJ MGP_FVBNJ_G0021017
protein coding gene Chr14:37606777-37678246 (-)
LP/J MGP_LPJ_G0021102
protein coding gene Chr14:39372611-39444586 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021042
protein coding gene Chr14:41483676-41561684 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021627
protein coding gene Chr14:38959573-39032036 (-)
PWK/PhJ MGP_PWKPhJ_G0020217
protein coding gene Chr14:34718263-34792114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020041
protein coding gene Chr14:35127149-35188386 (-)
WSB/EiJ MGP_WSBEiJ_G0020524
protein coding gene Chr14:39065099-39141868 (-)



Homology
more
  • Human Ortholog
    FERMT2, fermitin family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FERMT2, fermitin family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIND2, mig-2, MIG2, PLEKHC1, UNC112, UNC112B
  • Links
    NCBI Gene ID: 10979
    neXtProt AC: NX_Q96AC1
    UniProt: Q96AC1

  • Chr Location
    14q22.1; chr14:52857271-52951192 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4976
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FERMT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 6 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice are embryonic lethal at or before E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218952 NCBI Gene Model | MGI Sequence Detail 71322 C57BL/6J ±  kb
    transcript NM_001360525 RefSeq | MGI Sequence Detail 3276 C57BL/6  
    polypeptide Q8CIB5 UniProt | EBI | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      cDNA 155
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145587
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:260481 Guo L, et al., Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. J Cell Biol. 2018 Apr 2;217(4):1431-1451

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory