Mgat2
Gene Detail

Symbol Name ID

Mgat2 mannoside acetylglucosaminyltransferase 2 MGI:2384966

Synonyms

CDGS2, GNT2, GNT-II

Feature Type

protein coding gene

Genetic Map

Chromosome 12

28.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:69184157-69186770 bp, + strand From VEGA annotation of GRCm38   2614 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, MGAT2 type
Gene Tree: Mgat2

Human homologs

Human Homolog		MGAT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NCBI Gene ID		4247
neXtProt AC		NX_Q10469
Human Synonyms		CDG2A, CDGS2, GLCNACTII, GNT2, GNT-II
Human Chr (Location)		14q21; chr14:50087489-50090199 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MGAT2

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygous null mice recapitulate aspects of the phenotype exhibited by patients with congenital disorders of glycosylation (CDG), particularly type IIa. Most null mice died either embyronically or postnataly and exhibited muscular, gastrointestinal, hematologic, and osteogenic defects.

 
Human Diseases Modeled Using Mouse Mgat2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	oligosaccharide biosynthetic process, protein N-linked glycosylation, ...
Component	Golgi apparatus, Golgi stack, ...
Function	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (128)    Tissues (100)    Images (34)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	128

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023816 (Evidence)
Ensembl Gene Model	ENSMUSG00000043998 (Evidence)
Entrez Gene	217664 (Evidence)
DFCI	TC1577468, TC1616841
DoTS	DT.492549, DT.101378833, DT.97401891
NIA Mouse Gene Index	U014015
EC	2.4.1.143
Consensus CDS Project	CCDS25947.1
International Mouse Knockout Project Status	Mgat2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023816	VEGA Gene Model | MGI Sequence Detail	2614	C57BL/6J
transcript	OTTMUST00000058177	VEGA | MGI Sequence Detail	2614	Not Applicable
polypeptide	OTTMUSP00000028149	VEGA | MGI Sequence Detail	442	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007754	N-acetylglucosaminyltransferase II
Protein Ontology	PR:000010379	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

References

(Earliest) J:80661 Wang Y, et al., Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology. 2001 Dec;11(12):1051-70
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Other accession IDs

MGI:2144720