About   Help   FAQ
Mgat2
Gene Detail
 Symbol
Name
ID
Mgat2
mannoside acetylglucosaminyltransferase 2
MGI:2384966
Synonyms CDGS2, GNT2, GNT-II
Feature Type protein coding gene
Genetic Map
Chromosome 12
28.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:69184157-69186770 bp, + strand
From VEGA annotation of GRCm38

  2614 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, MGAT2 type
Gene Tree: Mgat2

Human
homologs
Human Homolog MGAT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NCBI Gene ID 4247
neXtProt AC  NX_Q10469
Human Synonyms  CDG2A, CDGS2, GLCNACTII, GNT2, GNT-II
Human Chr (Location)  14q21; chr14:49620771-49623481 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MGAT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice recapitulate aspects of the phenotype exhibited by patients with congenital disorders of glycosylation (CDG), particularly type IIa. Most null mice died either embyronically or postnataly and exhibited muscular, gastrointestinal, hematologic, and osteogenic defects.
 
Human Diseases Modeled Using Mouse Mgat2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Mgat2 interacts with 188 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process oligosaccharide biosynthetic process, protein N-linked glycosylation, ...
Component Golgi apparatus, Golgi stack, ...
Function alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (128)    Tissues (100)    Images (34)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 128
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023816 (Evidence)
Ensembl Gene ModelENSMUSG00000043998 (Evidence)
Entrez Gene217664 (Evidence)
DFCITC1577468, TC1616841
DoTSDT.492549, DT.101378833, DT.97401891
NIA Mouse Gene IndexU014015
EC2.4.1.143
Consensus CDS ProjectCCDS25947.1
International Mouse Knockout Project StatusMgat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023816 VEGA Gene Model | MGI Sequence Detail 2614 C57BL/6J ±  kb
transcript OTTMUST00000058177 VEGA | MGI Sequence Detail 2614 Not Applicable 
polypeptide OTTMUSP00000028149 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007754 N-acetylglucosaminyltransferase II
Protein Ontology PR:000010379 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
References (Earliest) J:80661 Wang Y, et al., Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology. 2001 Dec;11(12):1051-70
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)
Disease annotation references (1)
Other
accession IDs
MGI:2144720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory