About   Help   FAQ
Mgat2
Gene Detail
Symbol

Name
ID
Mgat2
mannoside acetylglucosaminyltransferase 2
MGI:2384966
Synonyms
CDGS2, GNT2, GNT-II
Feature Type
protein coding gene
Genetic Map
Chromosome 12
28.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:69184157-69186770 bp, + strand
From VEGA annotation of GRCm38

  2614 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MGAT2
Protein SuperFamily: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, MGAT2 type
Gene Tree: Mgat2

Human
homologs
MGAT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4247
neXtProt AC: NX_Q10469

Human Synonyms: CDG2A, CDGS2, GLCNACTII, GNT2, GNT-II

Human Chr (Location): 14q21; chr14:49620771-49623481 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MGAT2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice recapitulate aspects of the phenotype exhibited by patients with congenital disorders of glycosylation (CDG), particularly type IIa. Most null mice died either embyronically or postnataly and exhibited muscular, gastrointestinal, hematologic, and osteogenic defects.
 
Human Diseases Modeled in Mice Using Mgat2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Mgat2 interacts with 188 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (128)    Tissues (100)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mgat2    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023816 (Evidence)
Ensembl Gene Model ENSMUSG00000043998 (Evidence)
Entrez Gene 217664 (Evidence)
DFCI TC1577468, TC1616841
DoTS DT.492549, DT.97401891, DT.101378833
NIA Mouse Gene Index U014015
EC 2.4.1.143
Consensus CDS Project CCDS25947.1
International Mouse Phenotyping Consortium Status Mgat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023816 VEGA Gene Model | MGI Sequence Detail 2614 C57BL/6J ±  kb
transcript OTTMUST00000058177 VEGA | MGI Sequence Detail 2614 Not Applicable 
polypeptide OTTMUSP00000028149 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007754 N-acetylglucosaminyltransferase II
Protein Ontology PR:000010379 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
References
(Earliest) J:80661 Wang Y, et al., Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology. 2001 Dec;11(12):1051-70
(Latest) J:218408 Mul JD, et al., MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1065-72
All references(33)
Disease annotation references (1)
Other
accession IDs
MGI:2144720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory