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Spns2
Gene Detail
Symbol

Name
ID
Spns2
spinster homolog 2
MGI:2384936
Synonyms
MGC:37865
Feature Type
protein coding gene
Genetic Map
Chromosome 11
44.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:72451638-72489904 bp, - strand
From VEGA annotation of GRCm38

  38267 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPNS2
Gene Tree: Spns2

Human
homologs
SPNS2, spinster homolog 2 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 124976
neXtProt AC: NX_Q8IVW8

Human Chr (Location): 17p13.2; chr17:4498834-4539933 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Genomic Mutations involving Spns2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit symblepharon and impaired egress of T and B cells from the thymus and bone marrow, respectively. Mice homozygous for a different knock-out allele exhibit abnormal immune system, abnormal eye morphology and absent pinna reflex.
 
Phenotype Images(2)
Interactions
Spns2 interacts with 203 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process B cell homeostasis, bone development, ...
Component integral component of membrane, lysosomal membrane, ...
Function sphingolipid transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (100)    Tissues (13)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
cDNA source data(108)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase spns2 ; ZFIN spns2    NEW 
Molecular
reagents
All nucleic(108) cDNA(108)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000008085 (Evidence)
Ensembl Gene Model ENSMUSG00000040447 (Evidence)
Entrez Gene 216892 (Evidence)
UniGene 212812
DFCI TC1578159, TC1598484
NIA Mouse Gene Index U033028
Consensus CDS Project CCDS48841.1
International Mouse Phenotyping Consortium Status Spns2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008085 VEGA Gene Model | MGI Sequence Detail 38267 C57BL/6J ±  kb
transcript OTTMUST00000018365 VEGA | MGI Sequence Detail 3241 Not Applicable 
polypeptide OTTMUSP00000008441 VEGA | MGI Sequence Detail 549 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(11) UniProt(3)
Polymorphisms
SNPs within 2kb(297 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000015551 protein spinster homolog 2
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory