Spns2
Gene Detail

Symbol Name ID

Spns2 spinster homolog 2 MGI:2384936

Synonyms

MGC:37865

Feature Type

protein coding gene

Genetic Map

Chromosome 11

44.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:72451638-72489904 bp, - strand From VEGA annotation of GRCm38   38267 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:71040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Spns2

Human homologs

Human Homolog		SPNS2, spinster homolog 2 (Drosophila)
NCBI Gene ID		124976
neXtProt AC		NX_Q8IVW8
Human Chr (Location)		17p13.2; chr17:4402129-4443228 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit symblepharon and impaired egress of T and B cells from the thymus and bone marrow, respectively.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	B cell homeostasis, bone development, ...
Component	integral to membrane, membrane
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (100)    Tissues (13)    Images (21)
Theiler Stages: 23

Assay Type	Results
RNA in situ	100

cDNA source data(108)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(108) cDNA(108)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000008085 (Evidence)
Ensembl Gene Model	ENSMUSG00000040447 (Evidence)
Entrez Gene	216892 (Evidence)
UniGene	212812
DFCI	TC1578159, TC1598484
NIA Mouse Gene Index	U033028
Consensus CDS Project	CCDS48841.1
International Mouse Knockout Project Status	Spns2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008085	VEGA Gene Model | MGI Sequence Detail	38267	C57BL/6J
transcript	OTTMUST00000018365	VEGA | MGI Sequence Detail	3241	Not Applicable
polypeptide	OTTMUSP00000008441	VEGA | MGI Sequence Detail	549	Not Applicable

All sequences(33) RefSeq(4) UniProt(3)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000015551	protein spinster 2

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:188933 Nijnik A, et al., The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol. 2012 Jul 1;189(1):102-11
All references(32)