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Spns2 Gene Detail
Summary
  • Symbol
    Spns2
  • Name
    spinster homolog 2
  • Synonyms
    MGC:37865
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384936
    NCBI Gene: 216892
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72451638-72489904 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 44.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384936
protein coding gene Chr11:72451638-72489920 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018641
protein coding gene Chr11:73075217-73113491 (-)
A/J MGP_AJ_G0018609
protein coding gene Chr11:70343600-70382467 (-)
AKR/J MGP_AKRJ_G0018578
protein coding gene Chr11:72495641-72533904 (-)
BALB/cJ MGP_BALBcJ_G0018581
protein coding gene Chr11:70647031-70685291 (-)
C3H/HeJ MGP_C3HHeJ_G0018394
protein coding gene Chr11:72455090-72495245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019032
protein coding gene Chr11:75294887-75333156 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016675
protein coding gene Chr11:67177260-67215909 (-)
CAST/EiJ MGP_CASTEiJ_G0017949
protein coding gene Chr11:72818581-72856785 (-)
CBA/J MGP_CBAJ_G0018366
protein coding gene Chr11:78640905-78679167 (-)
DBA/2J MGP_DBA2J_G0018475
protein coding gene Chr11:69980875-70019044 (-)
FVB/NJ MGP_FVBNJ_G0018466
protein coding gene Chr11:69522897-69562318 (-)
LP/J MGP_LPJ_G0018546
protein coding gene Chr11:73587839-73626101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018489
protein coding gene Chr11:79183543-79226711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019074
protein coding gene Chr11:72683119-72721425 (-)
PWK/PhJ MGP_PWKPhJ_G0017722
protein coding gene Chr11:70604519-70642816 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017512
protein coding gene Chr11:72397377-72435322 (-)
WSB/EiJ MGP_WSBEiJ_G0018003
protein coding gene Chr11:72433402-72473106 (-)



Homology
more
  • Human Ortholog
    SPNS2, sphingolipid transporter 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPNS2, sphingolipid transporter 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 124976
    neXtProt AC: NX_Q8IVW8
    UniProt: Q8IVW8

  • Chr Location
    17p13.2; chr17:4498834-4539933 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 6 alleles in 8 genetic backgrounds
    3 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit symblepharon and impaired egress of T and B cells from the thymus and bone marrow, respectively. Mice homozygous for a different knock-out allele exhibit abnormal immune system, abnormal eye morphology and absent pinna reflex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040447 Ensembl Gene Model | MGI Sequence Detail 38267 C57BL/6J ±  kb
    transcript ENSMUST00000045303 Ensembl | MGI Sequence Detail 3241 Not Applicable  
    polypeptide ENSMUSP00000044418 Ensembl | MGI Sequence Detail 549 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 109

      Microarray probesets 2
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:259300 Fang V, et al., Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-gamma response. Nat Immunol. 2017 Jan;18(1):15-25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory